Aune, D, Vieira, AR, Chan, DSM et al. (6 more authors) (2012) Height and pancreatic cancer risk: A systematic review and meta-analysis of cohort studies. Cancer Causes and Control, 23 (8). 1213 - 1222 . ISSN 0957-5243
Abstract
Background Greater height has been associated with increased risk of several cancers, but epidemiological data on height and pancreatic cancer are inconclusive. We conducted a systematic review and meta-analysis of prospective studies to clarify these results. Methods PubMed and several other databases were searched up to September 2011. Prospective studies of height and pancreatic cancer were included. Summary relative risks were estimated by the use of a random effects model. Results We identified twelve cohort studies that were included in the meta-analysis. The summary RR per 5-cm increase in height was 1.07 (95 % CI: 1.03-1.12, I2 = 57 %). The results were similar among men and women. The summary estimate was attenuated when we included results from two pooled analyses together with these studies, summary RR = 1.03 (95 % CI: 1.00-1.07, I2 = 44 %). Conclusions This meta-analysis of cohort studies provides further evidence that greater adult attained height is associated with increased pancreatic cancer risk. However, given the unexplained heterogeneity, further studies are needed before a conclusion can be drawn.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2012, Springer Verlag. This is an author produced version of a paper published in Cancer Causes and Control. Uploaded in accordance with the publisher's self-archiving policy. The final publication is available at link.springer.com. |
Keywords: | Height, pancreatic cancer, systematic review, meta-analysis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 22 May 2013 09:24 |
Last Modified: | 17 Jan 2018 07:59 |
Published Version: | http://dx.doi.org/10.1007/s10552-012-9983-0 |
Status: | Published |
Publisher: | Springer Verlag |
Identification Number: | 10.1007/s10552-012-9983-0 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:75578 |