Binks, DA, Hodgson, RJ, Ries, ME et al. (4 more authors) (2013) Quantitative parametric MRI of articular cartilage: a review of progress and open challenges. British Journal of Radiology, 86 (1023). 20120163 - ? . ISSN 0007-1285
Abstract
With increasing life expectancies and the desire to maintain active lifestyles well into old age, the impact of the debilitating disease osteoarthritis (OA) and its burden on healthcare services is mounting. Emerging regenerative therapies could deliver significant advances in the effective treatment of OA but rely upon the ability to identify the initial signs of tissue damage and will also benefit from quantitative assessment of tissue repair in vivo. Continued development in the field of quantitative MRI in recent years has seen the emergence of techniques able to probe the earliest biochemical changes linked with the onset of OA. Quantitative MRI measurements including T(1), T(2) and T(1ρ) relaxometry, diffusion weighted imaging and magnetisation transfer have been studied and linked to the macromolecular structure of cartilage. Delayed gadolinium-enhanced MRI of cartilage, sodium MRI and glycosaminoglycan chemical exchange saturation transfer techniques are sensitive to depletion of cartilage glycosaminoglycans and may allow detection of the earliest stages of OA. We review these current and emerging techniques for the diagnosis of early OA, evaluate the progress that has been made towards their implementation in the clinic and identify future challenges in the field.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2013, British Institute of Radiology. This is an author produced version of a paper published in British Journal of Radiology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Animals, Cartilage, Articular, Cattle, Chondroitin Sulfates, Contrast Media, Gadolinium DTPA, Humans, Ligaments, Magnetic Resonance Imaging, Osteoarthritis, Patella, Sheep, Sodium, Tendons |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Musculoskeletal Disease (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Academic Unit of Medical Physics (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Physics and Astronomy (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 29 Apr 2013 08:17 |
Last Modified: | 05 Nov 2017 21:28 |
Published Version: | http://dx.doi.org/10.1259/bjr.20120163 |
Status: | Published |
Publisher: | British Insitute of Radiology |
Refereed: | Yes |
Identification Number: | 10.1259/bjr.20120163 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:75447 |