Porthouse, J., Birks, Y.F., Torgerson, D.J. et al. (3 more authors) (2004) Risk factors for fracture in a UK population: a prospective cohort study. Quarterly Journal of Medicine, 97 (9). pp. 569-574. ISSN 1460-2725
Abstract
BACKGROUND:
Common clinical risk factors for fracture in older women have been identified. To date, most of these risk factors have not been confirmed in a UK population.
AIM:
To confirm the important risk factors for fracture in older women.
DESIGN:
Comprehensive cohort study (CCS) with a nested randomized controlled trial.
METHODS:
The CCS included 4292 women aged >70 years. We assessed potential risk factors for fracture, and followed-up participants for 24 months for incidence of non-vertebral fractures.
RESULTS:
Odds ratios (ORs) for predicting any non-vertebral fracture were: previous fracture, 2.67 (95%CI 2.10–3.40); a fall in the last 12 months, 2.06 (95%CI 1.63–2.59); and age (per year increase), 1.03 (95%CI 1.01–1.05). ORs for predicting hip fracture were: previous fracture, 2.31 (95%CI 1.31–4.08); low body weight (<58 kg), 2.20 (95%CI 1.28–3.77); maternal history of hip fracture, 1.68 (95%CI 0.85–3.31); a fall in the last 12 months, 2.92 (95%CI 1.70–5.01); and age (per year increase), 1.09 (95%CI 1.04–1.13). ORs for predicting wrist fracture were: previous fracture, 2.29 (95%CI 1.56–3.34); and a fall in the last 12 months, 1.60 (95%CI 1.10–2.31). Being a current smoker was not associated with an increase in risk, and was consistent across all fracture types.
DISCUSSION:
Older women with the clinical risk factors identified in this study should be investigated for osteoporosis or offered preventive treatment.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | York RAE Import |
Date Deposited: | 13 Feb 2009 12:43 |
Last Modified: | 13 Feb 2009 12:43 |
Published Version: | http://dx.doi.org/10.1093/qjmed/hch097 |
Status: | Published |
Publisher: | Oxford University Press |
Refereed: | Yes |
Identification Number: | 10.1093/qjmed/hch097 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:7435 |