Healy, M.P., Parsons, A.F. and Rawlinson, J.G.T. (2005) Consecutive approach to alkenes that combines radical addition of phosphorus hydrides with Horner-Wadsworth-Emmons-type reactions. Organic Letters, 7 (8). pp. 1597-1600. ISSN 1523-7060
Abstract
Addition of diethyl thiophosphite to terminal alkenes, in the presence of a radical initiator, followed by deprotonation of the phosphonothioate and reaction with a ketone, offers a concise one-pot approach to substituted alkenes. This novel method, which can incorporate alkylation or acylation steps, can be applied to the stereoselective formation of sterically hindered tri- and tetrasubstituted alkenes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | York RAE Import |
Date Deposited: | 12 Mar 2009 12:26 |
Last Modified: | 12 Mar 2009 12:26 |
Published Version: | http://dx.doi.org/10.1021/ol050292e |
Status: | Published |
Publisher: | The American Chemical Society |
Identification Number: | 10.1021/ol050292e |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:7126 |
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