Quesada, E., Stockley, M., Ragot, J.P. et al. (3 more authors) (2004) A versatile, non-biomimetic route to the preussomerins: syntheses of (+ -)-preussomerins F, K and L. Organic and Biomolecular Chemistry, 2 (17). pp. 2483-2495. ISSN 1477-0520
Abstract
The first total syntheses of the title fungal metabolites preussomerins F, K and L are described and their structures confirmed thereby. The syntheses were achieved following a versatile, unified, non-biomimetic approach, which is easily extendable to prepare other known and novel members of this family. Key steps include the functionalisation of a 2-arylacetal anion, tandem one-pot Friedel–Crafts cyclisation–deprotection, regioselective substrate-directable hydrogenation and reductive-opening of epoxides.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | York RAE Import |
Date Deposited: | 12 Mar 2009 14:43 |
Last Modified: | 12 Mar 2009 14:43 |
Published Version: | http://dx.doi.org/10.1039/b407895k |
Status: | Published |
Publisher: | Royal Society Chemistry |
Identification Number: | 10.1039/b407895k |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:7122 |