Clarke, P.A., Martin, W.H.C., Hargreaves, J.M. et al. (2 more authors) (2005) The one-pot, multi-component construction of highly substituted tetrahydropyran-4-ones using the Maitland-Japp reaction. Organic and Biomolecular Chemistry, 3 (19). pp. 3551-3563. ISSN 1477-0520
Abstract
A one-pot, multi-component reaction for the synthesis of highly substituted tetrahydropyran-4-ones, based on the long forgotten Maitland–Japp reaction has been realised. Two different aldehydes and a derivative of a -ketoester can be condensed regioselectively in the presence of a Lewis acid to form tetrahydropyran-4-ones in excellent yields. The diastereoselectively of the reaction was found to be dependant upon the nature of the Lewis acid and the temperature at which the reaction was carried out. This procedure was also extended to the formation of tetrahydropyran-4-ones in greater than 95% enantiomeric excess.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | York RAE Import |
Date Deposited: | 12 Mar 2009 15:18 |
Last Modified: | 12 Mar 2009 15:18 |
Published Version: | http://dx.doi.org/10.1039/b508252h |
Status: | Published |
Publisher: | Royal Society Chemistry |
Identification Number: | 10.1039/b508252h |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:7119 |