Baseler, H.E., Brewer, A.A., Sharpe, L.T. et al. (3 more authors) (2002) Reorganization of human cortical maps caused by inherited photoreceptor abnormalities. Nature Neuroscience, 5 (4). pp. 364-370. ISSN 1097-6256
Abstract
We describe a compelling demonstration of large-scale developmental reorganization in the human visual pathways. The developmental reorganization was observed in rod monochromats, a rare group of congenitally colorblind individuals who virtually lack cone photoreceptor function. Normal controls had a cortical region, spanning several square centimeters, that responded to signals initiated in the all-cone foveola but was inactive under rod viewing conditions; in rod monochromats this cortical region responded powerfully to rod-initiated signals. The measurements trace a causal pathway that begins with a genetic anomaly that directly influences sensory cells and ultimately results in a substantial central reorganization.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Psychology (York) |
Depositing User: | York RAE Import |
Date Deposited: | 12 Mar 2009 16:21 |
Last Modified: | 12 Mar 2009 16:21 |
Published Version: | http://dx.doi.org/10.1038/nn817 |
Status: | Published |
Publisher: | Nature Publishing Group |
Identification Number: | 10.1038/nn817 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:7101 |