Whitehead, D.M., Jackson, T., McKeown, S.C. et al. (2 more authors) (2002) Application of X-ray photoelectron Sspectroscopy in determining the structure of solid-phase bound substrates. Journal Of Combinatorial Chemistry, 4 (4). pp. 255-257. ISSN 1520-4766
Abstract
The synthesis of compounds on solid supports has grown rapidly in the past 10 years, but one of the hurdles to the routine adoption of solid-supported chemistry is the limited number of analytical methods available to characterize resin-bound compounds. There have been methods developed for on-bead reaction monitoring of solid-phase reactions; both magic angle spinning (MAS) NMR1 and FTIR2 are useful techniques, but much solid-phase chemistry still relies on releasing the product from the solid support for validation. As a result, there still remains the need for complementary techniques that could quantify and/or identify functional groups prepared during solid-phase synthesis.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | York RAE Import |
Date Deposited: | 23 Apr 2009 13:31 |
Last Modified: | 23 Apr 2009 13:31 |
Published Version: | http://dx.doi.org/10.1021/cc020002a |
Status: | Published |
Publisher: | American Chemical Society |
Identification Number: | 10.1021/cc020002a |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:6570 |