Cronin, L., Foxon, S.P., Lusby, P.J. et al. (1 more author) (2001) Syntheses and structures of M(L)(X)BPh4 complexes {M = Co(II), Zn(II); L = cis-1,3,5-tris[3-(2-furyl)prop-2- enylideneamino]cyclohexane, X = OAc, NO3}: structural models of the active site of carbonic anhydrase. Journal Of Biological Inorganic Chemistry, 6 (4). pp. 367-377. ISSN 0949-8257
Abstract
The metal coordination geometries in the structures of the zinc(II) and cobalt(II) complexes of the ligand cis-1,3,5-tris[3-(2-furyl)prop-2-enylideneamino]cyclohexane (fr-protach) and with the anions nitrate and acetate are structural models for the active site of carbonic anhydrase. The acetate structures show a striking structural correlation with the metal coordination environments in the known bicarbonate forms of the enzyme. Such structures provide a basis for understanding the marked effect of different metal substitution on the catalytic rate of the enzyme.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Carbonic anhydrase; Triaminocyclohexane; Biomimicry; Zinc; Cobalt |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | York RAE Import |
Date Deposited: | 29 May 2009 11:08 |
Last Modified: | 29 May 2009 11:08 |
Published Version: | http://dx.doi.org/10.1007/s007750100211 |
Status: | Published |
Publisher: | Springer Science + Business Media |
Refereed: | Yes |
Identification Number: | 10.1007/s007750100211 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:6506 |