Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: A systematic review and economic evaluation

Abstract

The aim of this review was to examine the clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults. For the purposes of this review newer antiepileptic drugs (AEDs) included gabapentin (GBP) (Neurontin(R), Parke-Davis), lamotrigine (LTG) (Lamictal(R), GlaxoSmithKline), levetiracetam (LEV) (Keppra(R), UCB Pharma), oxcarbazepine (OXC) (Trileptal(R), Novartis Pharmaceuticals), tiagabine (TGB) [Gabatril(R), Cephalon (UK)], topiramate (TPM) (Topomax(R), Janssen-Cilag) and vigabatrin (VGB) (Sabril(R), Hoechst Marion Roussel). A concurrent review was performed by the West Midlands Health Technology Assessment Collaboration (WMHTAC), Birmingham, to examine the clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in children.

Metadata

Item Type:	Article
Authors/Creators:	Wilby, J Kainth, A Hawkins, N Epstein, D McIntosh, H McDaid, C https://orcid.org/0000-0002-3751-7260 Mason, A https://orcid.org/0000-0002-5823-3064 Golder, S https://orcid.org/0000-0002-8987-5211 O'Meara, S (smo4@york.ac.uk) Sculpher, M https://orcid.org/0000-0003-3746-9913 Drummond, M https://orcid.org/0000-0002-6126-0944 Forbes, C
Keywords:	ADD-ON THERAPY,QUALITY-OF-LIFE,REFRACTORY PARTIAL EPILEPSY,NEWLY-DIAGNOSED EPILEPSY,COMPLEX PARTIAL SEIZURES,PLACEBO-CONTROLLED TRIAL,PARTIAL-ONSET SEIZURES,RESISTANT PARTIAL EPILEPSY,GAMMA-VINYL-GABA,VISUAL-FIELD DEFECTS
Dates:	Published: May 2005
Institution:	The University of York
Academic Units:	The University of York > Faculty of Social Sciences (York) > Centre for Reviews and Dissemination (York) The University of York > Faculty of Social Sciences (York) > Centre for Health Economics (York) The University of York > Faculty of Sciences (York) > Health Sciences (York)
Depositing User:	Pure (York)
Date Deposited:	07 Jun 2012 15:29
Last Modified:	23 Jan 2025 00:05
Status:	Published
Refereed:	Yes
Related URLs:	http://www.hta.ac.uk/project/1304.asp
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:59216

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Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: A systematic review and economic evaluation

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