Oliver, S.E., Barrass, B., Gunnell, D.J. et al. (7 more authors) (2004) Serum Insulin-Like Growth Factor-I Is Positively Associated With Serum Prostate-Specific Antigen in Middle-Aged Men Without Evidence of Prostate Cancer. Cancer Epidemiology Biomarkers & Prevention, 13 (1). pp. 163-165. ISSN 1055-9965
Abstract
We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Hull York Medical School (York) |
Depositing User: | York RAE Import |
Date Deposited: | 10 Aug 2009 10:04 |
Last Modified: | 10 Aug 2009 10:04 |
Published Version: | http://dx.doi.org/10.1158/1055-9965.EPI-03-0102 |
Status: | Published |
Publisher: | American Association for Cancer Research |
Identification Number: | 10.1158/1055-9965.EPI-03-0102 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:5835 |