Phillips, G.D., Setzu, E. and Hitchcott, P.K. (2003) Facilitation of appetitive Pavlovian conditioning by d-amphetamine in the shell, but not the core, of the nucleus accumbens. Behavioral Neuroscience, 117 (4). pp. 675-684. ISSN 0735-7044
Abstract
The effects of postsession d-amphetamine within subregions of the ventral and dorsal striatum on appetitive Pavlovian learning were assessed. Rats acquired a conditioned approach response on presentation of a stimulus predictive of 10% sucrose solution (unconditioned stimulus [US]), but not during equally frequent presentations of a stimulus uncorrelated with the US. In Experiment 1, postsession d-amphetarnine infusions enhanced acquisition of conditioned responding, with no effect on control measures. In Experiment 2, rats received postsession d-amphetamine in the accumbens shell or core. Shell infusions facilitated conditioning; core infusions did not. In Experiment 3, dorsomedial striatal infusions of d-amphetamine also were ineffective. In sum, dopaminergic activation within the shell, but not the core, of the nucleus accumbens facilitates the acquisition of a Pavlovian association.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Psychology (York) |
Depositing User: | York RAE Import |
Date Deposited: | 24 Jul 2009 08:21 |
Last Modified: | 24 Jul 2009 08:21 |
Published Version: | http://dx.doi.org/10.1037/0735-7044.117.4.675 |
Status: | Published |
Publisher: | American Psychological Association |
Identification Number: | 10.1037/0735-7044.117.4.675 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:5658 |