Goode, NP, Shires, M, Khan, TN et al. (1 more author) (2004) Expression of alpha-actinin-4 in acquired human nephrotic syndrome: a quantitative immunoelectron microscopy study. Nephrology Dialysis Transplantation, 19 (4). 844 - 851 . ISSN 0931-0509
Abstract
The molecular basis for the alteration of glomerular podocyte phenotype in nephrotic syndrome probably involves adaptive changes of the actin cytoskeleton. alpha-Actinin-4 is an actin cross-linking protein that also interacts with intra- and intercellular adhesion molecules and elements of the transmembrane signal transduction pathway and is implicated in nephrotic syndrome by animal models and human genetic studies.
Metadata
| Item Type: | Article |
|---|---|
| Authors/Creators: |
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| Keywords: | Actinin, Adolescent, Adult, Aged, Child, Female, Gold, Humans, Male, Microfilament Proteins, Microscopy, Immunoelectron, Middle Aged, Nephrotic Syndrome |
| Dates: |
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| Institution: | The University of Leeds |
| Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) |
| Depositing User: | Symplectic Publications |
| Date Deposited: | 16 Apr 2012 11:18 |
| Last Modified: | 04 Nov 2016 01:15 |
| Published Version: | http://dx.doi.org/10.1093/ndt/gfg620 |
| Status: | Published |
| Publisher: | Oxford University Press |
| Identification Number: | 10.1093/ndt/gfg620 |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:43853 |
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