Marriott, H. M., Jackson, L. E., Wilkinson, T. S. et al. (8 more authors) (2008) Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia. American journal of respiratory and critical care medicine, 177 (8). pp. 887-895. ISSN 1535-4970
Abstract
During pneumococcal pneumonia, NADPH oxidase-derived reactive oxygen species are redundant for host defense but limit neutrophil recruitment and survival. Decreased NADPH oxidase-dependent reactive oxygen species production is well tolerated and improves disease outcome during pneumococcal pneumonia by removing neutrophils from the tight constraints of reactive oxygen species-mediated regulation.
Metadata
| Item Type: | Article |
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| Authors/Creators: |
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| Dates: |
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| Institution: | The University of Sheffield |
| Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Department of Infection & Immunity |
| Depositing User: | Miss Anthea Tucker |
| Date Deposited: | 29 Mar 2012 09:52 |
| Last Modified: | 29 Mar 2012 09:52 |
| Published Version: | http://dx.doi.org/10.1164/rccm.200707-990OC |
| Status: | Published |
| Publisher: | American Thoracic Society |
| Identification Number: | 10.1164/rccm.200707-990OC |
| Related URLs: | |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:43801 |
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