Clarke, Paul A. orcid.org/0000-0003-3952-359X, Zaytzev, Andrey V. and Whitwood, Adrian C. (2007) Pot, atom and step economic (PASE) synthesis of highly functionalized piperidines: a five-component condensation. Tetrahedron Letters. pp. 5209-5212. ISSN 0040-4039
Abstract
The diastereoselective pot, atom and step economic (PASE) synthesis of highly functionalized piperidines has been realized. The procedure simply involves mixing methyl acetoacetate, 2 equiv of aldehyde and 2 equiv of aniline together in the presence of InCl3. In most cases the piperidine precipitates out of solution. (c) 2007 Elsevier Ltd. All rights reserved.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | piperidines,PASE,one-pot,multi-component,MAITLAND-JAPP REACTION,IDEAL SYNTHESIS,TETRAHYDROPYRAN-4-ONES,CONSTRUCTION,AMINES,WATER |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number EPSRC UNSPECIFIED |
Depositing User: | Ms Diana Hilmer |
Date Deposited: | 15 Oct 2007 16:46 |
Last Modified: | 21 Jan 2025 17:12 |
Published Version: | https://doi.org/10.1016/j.tetlet.2007.05.141 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.tetlet.2007.05.141 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:3384 |