Bungay, Cameron J., Hughes, Owen R., Zarkic, Andrej et al. (4 more authors) (2026) Synthesis of medium-sized rings via conjugate addition/ring expansion (CARE) cascade reactions of diketopiperazines and related bislactams. ARKIVOC. 202612610. ISSN: 1424-6376
Abstract
A Conjugate Addition/Ring Expansion (CARE) cascade approach has been used for the ring expansion of acryloyl imides derived from 6-membered ring diketopiperazines and 7-membered ring bislactams. Using this approach, a library of 10-and 11-membered ring cyclic triamides (small cyclic peptides) was prepared directly from the acryloyl imide starting materials, via reaction with primary amines at room temperature. [Image In Abstract].
Metadata
| Item Type: | Article |
|---|---|
| Authors/Creators: |
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| Copyright, Publisher and Additional Information: | © Authors 2026 |
| Keywords: | amide,diketopiperazine,Medium-sized rings,rearrangement,ring expansion |
| Dates: |
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| Institution: | The University of York |
| Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
| Funding Information: | Funder Grant number EUROPEAN COMMISSION 101044024 |
| Date Deposited: | 09 Sep 2026 11:10 |
| Last Modified: | 21 Oct 2026 23:40 |
| Published Version: | https://doi.org/10.24820/ark.5550190.p012.610 |
| Status: | Published |
| Refereed: | Yes |
| Identification Number: | 10.24820/ark.5550190.p012.610 |
| Related URLs: | |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:245316 |
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Filename: TP-12610OP_published_mainmanuscript.pdf
Description: Synthesis of medium-sized rings via Conjugate Addition/Ring Expansion (CARE) cascade reactions of diketopiperazines and related bislactams
Licence: CC-BY 2.5

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