Structural basis for uracil removal from DNA by human SMUG1

Ludäscher, J.M. orcid.org/0009-0005-7242-5133, Scaletti Hutchinson, E., Vila-Julià, G. orcid.org/0000-0001-5576-7442 et al. (12 more authors) (2026) Structural basis for uracil removal from DNA by human SMUG1. Nature Communications, 17 (1). 4809. ISSN: 2041-1723

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© 2026 The authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Keywords: Uracil; Humans; Uracil-DNA Glycosidase; DNA; Excision Repair; Molecular Dynamics Simulation; Fluorouracil; Pentoxyl; Crystallography, X-Ray; DNA Repair; Protein Binding
Dates:
  • Submitted: 27 October 2025
  • Accepted: 24 April 2026
  • Published (online): 2 June 2026
  • Published: 2 June 2026
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield)
Date Deposited: 13 Jul 2026 14:08
Last Modified: 15 Jul 2026 09:02
Status: Published
Publisher: Springer Science and Business Media LLC
Refereed: Yes
Identification Number: 10.1038/s41467-026-72937-0
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