Dwarakanath, A., Ghosh, D., Palissery, V. et al. (2 more authors) (2026) Relationship between cognitive failures, sleepiness and road traffic incidents in patients with untreated Obstructive Sleep Apnoea (OSA) and controls. ERJ Open Research. 01544-2025. ISSN: 2312-0541 (In Press)
Abstract
Introduction
Current guidelines emphasize assessing ‘excessive sleepiness’ and severity of sleep disordered breathing (SDB) when advising patients with OSA about driving. However, accidents can occur due to lack of concentration and poor reactions. The Cognitive Failures Questionnaire (CFQ) measures self-reported cognitive deficits in the completion of simple everyday tasks. We investigated the relationship between drivers’ cognitive capability and the severity of SDB, sleepiness and self-reported driving incidents.
Methods
348 patients (n=150, exploratory; n= 198, validation) considered for a trial of CPAP and 173 controls (n=105, exploratory; n=68, validation) matched for age and driving experience completed questionnaires that included the CFQ and a driving questionnaire.
Results
Compared to controls, patients had a higher total CFQ score (37 +/- 18 v/s 28 +/- 12, p= <0.0001, 95% CI= −13.3 to −7.3) and more self-reported driving incidents (accidents and/or near misses in the last year) (38% v/s 10%; OR=2.6; 95% CI= 2.79 to 8.34; p= 0.0005). Sleepiness rather than severity of SDB, predicted a higher CFQ score in patients compared to controls, both in the exploratory and validation cohorts. Self-reported driving incidents were significantly more frequent in patients who reported a higher degree of sleepiness (ESS >10; 40% v/s ESS <10 20%, OR=2.6; 95% CI=1.5 to 4.5; p= 0.0005). CFQ score was also a predictor of driving incidents.
Conclusions
Sleepiness and cognitive dysfunction, rather than severity of SDB predicts driving incident risk. The CFQ may identify a different aspect of accident risk and therefore may be useful in assessing fitness to drive in patients with OSAS.
Metadata
| Item Type: | Article |
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| Authors/Creators: |
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| Dates: |
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| Institution: | The University of Leeds |
| Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > Institute for Transport Studies (Leeds) |
| Date Deposited: | 17 Apr 2026 07:54 |
| Last Modified: | 08 May 2026 10:16 |
| Status: | In Press |
| Publisher: | European Respiratory Society |
| Identification Number: | 10.1183/23120541.01544-2025 |
| Sustainable Development Goals: | |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:240037 |


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