An ALS-Associated Mutation in the C-terminal α-helix of TDP-43 Uncouples Condensate Formation and Amyloid Assembly

Byrd, E.J. orcid.org/0000-0002-9876-1400, Crossley, J.A. orcid.org/0000-0002-6656-1578, Chau, C.C.C. orcid.org/0000-0002-3134-6798 et al. (2 more authors) (Accepted: 2026) An ALS-Associated Mutation in the C-terminal α-helix of TDP-43 Uncouples Condensate Formation and Amyloid Assembly. Protein Science. ISSN: 0961-8368 (In Press)

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Item Type: Article
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This is an author produced version of an article accepted for publication in Protein Science, made available via the University of Leeds Research Outputs Policy under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
Dates:
  • Accepted: 26 March 2026
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds)
Funding Information:
Funder
Grant number
Wellcome Trust
220628/Z/20/Z
Royal Society
RGS\R2\222357
BBSRC (Biotechnology and Biological Sciences Research Council)
BB/X003086/1
Date Deposited: 09 Apr 2026 08:31
Last Modified: 14 May 2026 08:26
Status: In Press
Publisher: Wiley
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