Comprehensive bulk and single-cell RNA sequencing uncovers senescence-associated biomarkers in therapeutic mesenchymal stem cells

Pekker, E., Qorri, E., Enyedi, M.Z. et al. (8 more authors) (2025) Comprehensive bulk and single-cell RNA sequencing uncovers senescence-associated biomarkers in therapeutic mesenchymal stem cells. Scientific Reports. ISSN: 2045-2322

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • Pekker, E.
  • Qorri, E.
  • Enyedi, M.Z.
  • Szukacsov, V.
  • Ayaydin, F.
  • Szabó-Kriston, É
  • Csányi, B.
  • Mórocz, M.
  • Sükösd, F.
  • Kiss-Tóth, E.
  • Haracska, L.
Copyright, Publisher and Additional Information:

© 2025 The Authors. Except as otherwise noted, this author-accepted version of a journal article published in Scientific Reports is made available via the University of Sheffield Research Publications and Copyright Policy under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/

© 2025 This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords: Animal model; Biomarkers; Mesenchymal stem cell; Senescence; Transcriptomics
Dates:
  • Submitted: 3 July 2025
  • Accepted: 26 November 2025
  • Published (online): 1 December 2025
  • Published: 1 December 2025
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Date Deposited: 09 Dec 2025 08:56
Last Modified: 09 Dec 2025 08:56
Status: Published online
Publisher: Springer Science and Business Media LLC
Refereed: Yes
Identification Number: 10.1038/s41598-025-30633-x
Related URLs:
Open Archives Initiative ID (OAI ID):

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