Cost-effectiveness of procalcitonin-guided antibiotic duration for hospitalized patients with sepsis

Stevenson, M. orcid.org/0000-0002-3099-9877, Forsyth, J.E., Hossain, A. et al. (525 more authors) (2025) Cost-effectiveness of procalcitonin-guided antibiotic duration for hospitalized patients with sepsis. Critical Care, 29 (1). 508. ISSN: 1364-8535

Abstract

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Item Type: Article
Authors/Creators:
  • Stevenson, M. ORCID logo https://orcid.org/0000-0002-3099-9877
  • Forsyth, J.E.
  • Hossain, A.
  • Lall, R.
  • Dark, P.
  • Carlson, G.
  • Naisbitt, M.J.
  • Kay, D.
  • Barber, S.
  • Parez, J.
  • Lee, S.
  • Doonan, R.
  • Swindells, L.
  • Pendlebury, J.
  • Holden, J.
  • Hadfeild, J.
  • Naisbitt, J.
  • Claxton, A.
  • Parkin, E.
  • Horner, D.
  • Sukumarian, A.
  • Gyamerah, B.
  • Duncombe, A.
  • Taylor, C.
  • Habeichi, W.
  • Borzomato, J.
  • Ferris, P.
  • Roberts, J.
  • Clayton, J.
  • Macdonald, J.
  • Tully, R.P.
  • Drummond, A.
  • Dearden, J.
  • Mulcahy, M.
  • Blessen, C.
  • Vian-Michael, A.
  • O’Connor, G.
  • Scargill, J.
  • Winnard, S.
  • Clayton, J.C.
  • Welters, I.D.
  • Williams, K.
  • Shaw, D.
  • Waugh, V.
  • Patrick-Heselton, J.
  • Paisley, C.
  • Phillips, S.
  • Johnson, E.
  • Roman, J.F.
  • Martinez, M.L.
  • Mahiya, A.
  • Watkin, D.
  • Thomas, Z.
  • Davison, A.
  • Farina, S.
  • Norris, M.
  • Manes, S.
  • Yuan, J.-X.
  • Colfar, J.
  • Lythgoe, C.
  • Almafreji, I.
  • Bailey, L.
  • Parker, R.J.
  • Turner-Bone, I.
  • Wilding, L.
  • Lloyd, M.
  • Murrant, H.
  • Smith, L.
  • Morton, B.
  • Middleton, D.
  • McCaig, W.
  • Hughes, A.
  • Fuller, L.
  • Perkins, G.
  • Gresty, J.
  • Reeves, E.
  • Melody, T.
  • Taylor, H.
  • Bawa, S.
  • Maliaykal, C.
  • McIver, W.
  • Mooradun, M.
  • Mohamed, T.
  • Willis, H.
  • Butler, A.
  • Hooper, A.
  • Boulton, A.
  • Linhartova, L.
  • Smith, R.
  • Park, D.
  • Dennis, A.
  • Yeung, J.
  • Ebrahim, H.
  • Crooks, N.
  • Milton-White, S.
  • Ballinger, S.
  • Carling, N.
  • Sampson, J.
  • Norman, C.
  • Thomas, M.
  • Nance, A.
  • Evans, E.
  • Horton, L.
  • Whitehouse, T.
  • Clark, A.
  • Ratcliffe, L.
  • Casey, A.
  • Dooley, N.
  • Ellis, K.
  • Sheridan, C.
  • Moody, L.
  • Mulholland, P.
  • Webster, R.
  • Harkett, S.
  • Beddows, S.
  • Dooley, C.
  • Reda, E.
  • Goundry, S.
  • Spruce, E.
  • Veenith, T.
  • Parekh, D.
  • Walmsley, N.
  • Saba, M.
  • Gill, R.
  • Thomas, E.
  • Patel, J.
  • Bangash, M.
  • Roy, A.
  • Rostron, A.
  • Woods, L.
  • Cornell, S.
  • Rogerson, K.
  • Boxall, J.
  • Burns, T.
  • Cooper, S.
  • Knight, K.
  • Constable, S.
  • Kenny, L.
  • Vernazza, J.
  • Richardson, M.
  • Bickerton, M.
  • Camplejohn, A.
  • Cope, R.
  • Sheriff, J.
  • Whiteley, S.
  • Ridley, M.
  • Gould, R.
  • Perrin, S.
  • Wilby, E.
  • Trott, S.
  • Salada, S.
  • Watts, S.
  • Friar, Z.
  • Ogg, B.
  • Howcroft, C.
  • Long, K.
  • Baker, H.
  • Watson, J.
  • Sedgwick, J.
  • McMullan, R.
  • McNamee, J.
  • McAuley, D.
  • McGuigan, P.
  • Ward, K.
  • Ward, J.
  • O’Neill, A.
  • Finn, S.
  • Collins, E.
  • Green, J.
  • Turley, C.
  • Quinn, G.
  • Adams, M.
  • Wright, C.
  • McKeeman, G.
  • Loughlin, R.
  • Reilly, L.
  • Gallagher, H.
  • Coward, S.
  • Morrison, R.
  • Lawton, T.
  • Robinson, A.
  • Azad, R.
  • Kitching, M.
  • Cockcroft, C.
  • Akeroyd, L.
  • Todd, J.
  • Kimachia, S.
  • Burgess, L.
  • Bano, S.
  • Hellyer, T.P.
  • McCullagh, I.J.
  • Hamilton, S.
  • Gulati, A.
  • Brown, B.
  • Grieveson, S.
  • Shrestha, T.
  • Storey, I.
  • Simoes, F.
  • Calder, V.
  • Hays, C.
  • Babio-Galan, M.
  • White, D.
  • Collins, J.
  • Dunn, L.
  • Taylor, S.
  • Gavina, L.
  • Wilkinson, T.
  • Garcia, P.
  • Butler, L.
  • Savage, J.
  • Harwood, J.
  • Cook, S.
  • Shelton, J.
  • Clement, I.
  • Burn, S.
  • Carroll, N.
  • Clark, L.
  • Ferguson, L.
  • Foggett, S.
  • Hague, A.
  • Handley, T.
  • Hewison, C.
  • Kitchener, S.
  • McEachan, L.
  • McEwen, N.
  • Perry, R.
  • Purdy, O.
  • Thomson, A.
  • Williams, S.
  • Balasubramaniam, M.
  • Flanagan, R.
  • McKenna, E.
  • Latham, S.
  • Hollick, D.
  • Pakou, G.
  • Filipe, H.
  • McNeil, M.
  • Mingo, S.
  • Veiga, C.
  • Teoh, P.C.
  • Maharajh, A.
  • De Neef, M.
  • Cole, C.
  • Solkar, S.
  • Okotete, O.
  • Singer, M.
  • Wilson, C.
  • Brealey, D.
  • MacCallum, N.
  • Hass, I.
  • Bercades, G.
  • Smyth, D.
  • Martir, G.
  • Reyes, A.
  • Martinez, M.A.Z.
  • Gallagher, L.
  • Omer, H.
  • Bannard-Smith, J.
  • Paripoorani, D.
  • Taylor, C.
  • Yates, G.
  • Wylie, K.
  • Salah, S.
  • Quilty, F.
  • Felton, T.W.
  • Alexander, P.D.G.
  • Ward, L.
  • Rothwell, J.
  • George, S.
  • Currie, H.
  • Sellers, K.
  • Adhikarla, A.
  • Rajasekar, J.
  • Purvis, S.
  • Garg, I.
  • Jagannathan, V.
  • Corr, H.
  • Stefaniak, M.
  • Sinclair, S.
  • Lynch, C.
  • Gibson, B.
  • Toth-Tarsoly, P.
  • Auer, Z.
  • Law, D.
  • Singh, J.
  • Oram, S.
  • Zaki, A.
  • Dodd, A.
  • Deacon, B.
  • Roche, L.
  • Jones, L.
  • Smeaton, J.
  • Agravante, K.
  • Akinyoola, O.
  • Turner, K.
  • Pugh, J.
  • Evans, S.
  • Mellish, L.
  • Rees, A.
  • Lewis, G.
  • Burke, J.
  • Bromage, N.
  • Llewellyn, N.
  • Evans, J.
  • Constantino, M.
  • Subudhi, C.P.K.
  • Chu, C.
  • Edwards, K.
  • Gupta, R.
  • Williams, C.
  • Mashangombe, L.
  • Javed, M.
  • Morris, A.
  • Sampson, J.
  • Gibbins, A.
  • Peters, C.
  • Meredith, M.
  • Baddeley, A.
  • Baidoo, A.
  • Harvey, D.
  • McCoy, A.
  • Lubbock, S.
  • Ford, D.
  • Clark, A.
  • Lloyd, L.
  • Habib, M.
  • Clark, G.
  • King, I.
  • Goode, C.
  • Sellick, A.
  • Sharma, S.
  • Assi, A.
  • Dengate, J.
  • Grice, M.
  • Brammer, L.
  • Ajonu, C.
  • Redgate, S.
  • Smith, W.
  • Khakh, M.
  • Howson-Wells, H.
  • Atkin, S.
  • Casbon, M.
  • Olsen, F.
  • Mistry, B.
  • Mitchinson, V.
  • Talbot, A.
  • Clayton, J.
  • Laha, S.
  • Raghunath, S.M.
  • Fonseca, A.J.
  • Williams, A.
  • Connor, S.
  • Allock, R.
  • Halsall, L.
  • McMullen, S.
  • Clayton, J.C.
  • Jutsum, F.
  • Price, L.
  • Pajak, S.
  • Gibson, H.
  • Bates, M.
  • Reid, K.
  • Bland, A.
  • Stephens, A.
  • Donaldson, D.
  • Beekes, M.
  • Stickley, J.
  • Adams, C.
  • Bowes, A.
  • Jose, S.
  • Manetas-Stavrakakis, N.
  • Wilcox, R.
  • Rikunenko, R.
  • Houghton, M.
  • Donnelly, A.
  • Summers, J.
  • Mowatt, C.
  • Richmond, K.
  • Jones, R.
  • Davie, T.
  • Barnsley, M.
  • Pursglove, M.
  • Pearce, J.
  • Lane, P.
  • Cole, N.
  • Phillips, M.
  • Jasiewicz, J.
  • Hamad, S.
  • Sharma, J.
  • Adeeb, M.
  • Qasim, M.
  • Barnsley, L.
  • Walton, L.
  • Wright, C.
  • Kaura, H.
  • McCormack, C.
  • Latham, D.
  • Wynne, E.
  • McCormack, C.
  • Richmond, K.
  • Gabriel, C.
  • Lowsby, R.
  • Matovu, E.
  • Pagett, K.
  • Maren, D.
  • Adeyemo, T.
  • David, H.
  • Quiambao, M.
  • Harold, J.
  • Clarke, S.
  • Gurov, V.
  • Mkandhla, A.
  • Duff, C.
  • Duce, H.
  • Karangoda, D.
  • Treus, E.
  • Howard, L.
  • Luck, G.
  • Ross, A.
  • Belsham, M.
  • Abu-Hijleh, S.
  • Thompson, C.
  • Gellamucho, M.
  • Delaney, J.
  • Davies, M.
  • Sernicola, E.
  • Bailey, L.
  • Cope, A.
  • Hudson, C.
  • Mohyddin, U.
  • Lee, J.
  • Storey-Waters, B.
  • Halliday, F.
  • Mathew, G.
  • Birch, S.
  • Denmade, C.
  • White, S.
  • Clare, R.
  • Huang, Y.-W.J.
  • Herbert, D.
  • Rowbottom, L.
  • McGrady, M.
  • Lone, N.I.
  • Walsh, T.S.
  • Amamio, M.
  • Andrew, G.
  • Barclay, L.
  • Birch, S.
  • Briton, K.
  • Butt, L.-M.
  • Clark, S.
  • Crossan, J.
  • Doverman, K.
  • Gillies, M.
  • Griffith, D.
  • Hope, D.
  • Kefala, K.
  • Laurenson, I.
  • Lone, N.
  • Macdonald, L.
  • Marshall, C.
  • McCulloch, C.
  • McNeill, G.
  • Rea, N.
  • Simpson, S.
  • Singleton, J.
  • Thompson, J.
  • Czarniak, E.
  • Nieto, O.L.M.
  • Bonner, S.
  • Henning, J.
  • Thompson, A.
  • Jones, J.
  • Liggett, S.
  • Mower, C.
  • Bircham, S.
  • Kamangu, B.
  • Shoremekun, A.
  • Ratnakumar, A.
  • Hugill, K.
  • Thomas, M.
  • Thomas, P.
  • Worner, R.
  • Borislavova, B.
  • Hayes, K.
  • Faulkner, B.
  • Gendall, E.
  • Goff, E.
  • Blackmore, H.
  • Spivey, M.
  • Bean, S.
  • Burt, K.
  • Patterson, A.
  • Vipond, L.
  • Martin, M.
  • Vallotton, N.
  • Waterman, S.
  • Kelsey, M.
  • Zuriaga-Alvaro, A.
  • Mostoles, L.
  • Pratley, A.
  • Amiruddin, N.
  • Ashby, H.
  • Wood, G.
  • Priestley, G.
  • Antil, P.
  • Carter, J.
  • Yates, D.
  • Ferguson, R.
  • Carter, H.
  • Cinquina, Z.
  • Ghuman, B.K.
  • Manazar, U.
  • Richards, G.
  • McNeil, H.C.
  • Young, K.K.
  • Gordon, A.C.
  • Mouncey, P.R.
  • Wilson, P.
  • Williams, D.
  • Jardine, C.
  • Craik, K.
  • Anderson, J.
  • Wild, L.
  • Cotterall, S.
  • Austin, M.
  • Wilkinson, M.
  • Harbison, N.
Copyright, Publisher and Additional Information:

© The Author(s) 2025. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Keywords: Antibiotic duration; Antibiotics; Cost-effectiveness; Health economics; Procalcitonin; Sepsis; Humans; Procalcitonin; Sepsis; Cost-Benefit Analysis; Anti-Bacterial Agents; Quality-Adjusted Life Years; Biomarkers; Male; Middle Aged; Hospitalization; Female; Aged; Intensive Care Units
Dates:
  • Accepted: 17 October 2025
  • Published (online): 28 November 2025
  • Published: 28 November 2025
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Funding Information:
Funder
Grant number
NATIONAL INSTITUTE FOR HEALTH RESEARCH
UNSPECIFIED
Date Deposited: 05 Dec 2025 12:52
Last Modified: 05 Dec 2025 12:52
Status: Published
Publisher: Springer Science and Business Media LLC
Refereed: Yes
Identification Number: 10.1186/s13054-025-05732-w
Related URLs:
Sustainable Development Goals:
  • Sustainable Development Goals: Goal 3: Good Health and Well-Being
Open Archives Initiative ID (OAI ID):

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