Brockdorff, M., Calmé, B., Wang, T. et al. (7 more authors) (2026) Combining tethered and untethered magnetic robots via a magnetically triggerable latch for target payload delivery and retrieval. Science Advances, 12 (1). eadu6025. ISSN: 2375-2548
Abstract
The reach and scope of minimally invasive surgical procedures can be transformed via the development of continuum robots. Through soft, flexible structures and accurate navigation, previously inaccessible anatomical regions can be safely reached. Dependent on both actuation mode and clinical application, however, rigidity and miniaturization potential can still present substantial challenges. Magnetic soft continuum robots (mSCRs) offer promising solutions to these key questions. Furthermore, micrometer- to millimeter-scale untethered magnetic robots (mUMRs) offer unparalleled miniaturization potential enabling targeted therapeutic delivery. Leveraging the benefits of magnetic actuation, this study introduces a bespoke, continuously magnetized catheter that synergizes the navigational strengths of mSCRs with the functional effectiveness of mUMRs to precisely deliver drug-doped payloads to otherwise unreachable regions deep within the anatomy. In particular, this system uses a magnetic latching mechanism, ensuring precise drug delivery and efficient retrieval, demonstrated in an ex vivo porcine kidney model for organ transplantation–related immunosuppressant delivery.
Metadata
| Item Type: | Article |
|---|---|
| Authors/Creators: |
|
| Copyright, Publisher and Additional Information: | © 2026 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Dates: |
|
| Institution: | The University of Leeds |
| Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Electronic & Electrical Engineering (Leeds) |
| Funding Information: | Funder Grant number EPSRC (Engineering and Physical Sciences Research Council) EP/V009818/1 EU - European Union EP/Y037235/1 EU - European Union 818045 |
| Date Deposited: | 25 Nov 2025 12:30 |
| Last Modified: | 22 Apr 2026 13:01 |
| Status: | Published |
| Publisher: | American Association for the Advancement of Science |
| Identification Number: | 10.1126/sciadv.adu6025 |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:234772 |
Download
Filename: sciadv.adu6025.pdf
Licence: CC-BY 4.0
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)