EndoCompass project: research roadmap for adrenal and cardiovascular endocrinology

Abstract

Background

Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project—a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.

Methods

Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in adrenal endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.

Results For adrenal disorders, research priorities span primary and secondary adrenal insufficiency, adrenal tumours, and endocrine hypertension. Key areas include development of biomarkers and replacement therapies, improved understanding of disease mechanisms, diagnostic procedure optimization, and establishment of pan-European registries. Special emphasis is placed on personalized treatment approaches.

Conclusions

The adrenal component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into adrenal disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of adrenal disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

Metadata

Item Type:	Article
Authors/Creators:	Husebye, E.S. Assié, G. Krone, N. https://orcid.org/0000-0002-3402-4727 Achermann, J.C. Altieri, B. https://orcid.org/0000-0003-2616-3249 Amar, L. https://orcid.org/0000-0003-3942-4276 Araujo-Castro, M. Brown, M.J. Casey, R.T. Claahsen-van der Grinten, H.L. Davies, E. https://orcid.org/0000-0001-8128-5404 Deinum, J. https://orcid.org/0000-0003-2465-1986 Flück, C.E. Kastelan, D. Kroiss, M. Mulatero, P. https://orcid.org/0000-0002-5480-1116 Laakso, S. https://orcid.org/0000-0002-5588-7855 Pearce, S.H. Reincke, M. https://orcid.org/0000-0002-9817-9875 Reisch, N. Robledo, M. https://orcid.org/0000-0001-6256-5902 Ronchi, C.L. Vassiliadi, D.A. Wiegering, V. Zennaro, M.-C.
Copyright, Publisher and Additional Information:	© The Author(s) 2025. Published by Oxford University Press on behalf of European Society of Endocrinology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords:	EndoCompass; adrenal; cardiovascular; funding, roadmap; adrenal insufficiency adrenal tumors endocrine hypertension
Dates:	Accepted: 9 May 2025 Published (online): 17 October 2025 Published: October 2025
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Date Deposited:	20 Oct 2025 14:48
Last Modified:	20 Oct 2025 14:48
Status:	Published
Publisher:	Oxford University Press (OUP)
Refereed:	Yes
Identification Number:	10.1093/ejendo/lvaf063
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:233251

Download

Published Version

Filename: lvaf063.pdf

Licence: CC-BY 4.0

CLICK TO DOWNLOAD

CORE (COnnecting REpositories)

EndoCompass project: research roadmap for adrenal and cardiovascular endocrinology

Abstract

Metadata

Download

Published Version

Export

Statistics