Rational Engineering of a Pseudaminic Acid Synthase Enzyme Enables Access to a 3-Fluoro Sugar with Motility Inhibition in Bacterial Pathogens

Metadata

Item Type:	Article
Authors/Creators:	JEFFRIES, JAMES WALKLETT, ABBY Hatton, Natasha (natasha.hatton@york.ac.uk) KOWALSKI, BARTOSZ Keenan, TESSA (tessa.keenan@york.ac.uk) Munjoma, Lickson Haigh, Richard Bayliss, Christopher THOMAS, GAVIN HUGH https://orcid.org/0000-0002-9763-1313 FASCIONE, MARTIN ANTHONY https://orcid.org/0000-0002-0066-4419
Copyright, Publisher and Additional Information:	© 2025 Wiley-VCH GmbH. This is an author-produced version of the published paper. Uploaded in accordance with the University’s Research Publications and Open Access policy.
Dates:	Accepted: 14 October 2025 Published (online): 23 October 2025
Institution:	The University of York
Academic Units:	The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Biology (York)
Funding Information:	Funder Grant number EUROPEAN COMMISSION 101044024
Date Deposited:	17 Oct 2025 13:30
Last Modified:	05 Nov 2025 14:00
Published Version:	https://doi.org/10.1002/anie.202515851
Status:	Published online
Refereed:	Yes
Identification Number:	10.1002/anie.202515851
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:233180