Practical guidance for conducting high-quality and rapid interim analyses in adaptive clinical trials

Mossop, H. orcid.org/0000-0002-6260-3734, Walmsley, Z. orcid.org/0000-0002-1253-6668, Wilson, N. orcid.org/0000-0001-5908-1720 et al. (19 more authors) (2025) Practical guidance for conducting high-quality and rapid interim analyses in adaptive clinical trials. BMC Medicine, 23. 528.

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Item Type: Article
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© 2025 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords: Adaptive trial; Interim analysis; Trial conduct; Humans; Research Design; Adaptive Clinical Trials as Topic; Clinical Trials as Topic
Dates:
  • Accepted: 22 August 2025
  • Published (online): 1 October 2025
  • Published: 1 October 2025
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Date Deposited: 02 Oct 2025 15:23
Last Modified: 02 Oct 2025 15:23
Status: Published
Publisher: BioMed Central
Refereed: Yes
Identification Number: 10.1186/s12916-025-04362-x
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Open Archives Initiative ID (OAI ID):

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