Jeong, H. orcid.org/0000-0002-1613-0198, Luo, T., Kang, M. et al. (5 more authors) (2025) Neuroimaging findings of adolescent depression: a review by the Research Domain Criteria (RDoC) framework. Psychiatry Research: Neuroimaging, 347. 111917. ISSN: 0925-4927
Abstract
This review examines neuroimaging studies on adolescent depression (AD) within the Research Domain Criteria (RDoC) framework, focusing on fMRI, DTI, and EEG findings. The research highlights disrupted connectivity in several neural networks—such as the affective, reward processing, cognitive control, and default mode networks—that underpin emotional and cognitive dysfunctions in AD. Notably, hypoconnectivity in the affective and cognitive control networks correlates with deficits in emotional processing and executive functioning, while hyperactivity in the default mode network relates to excessive self-referential thoughts. Additionally, blunted reward responses and frontal–striatal connectivity are discussed alongside the therapeutic potential of cognitive behavioral therapy (CBT) to modulate these dysfunctional circuits. Despite these insights, variability in findings due to small sample sizes and diverse methodologies suggests a need for further research to validate neuroimaging biomarkers for treatment efficacy and to explore less studied treatments like ECT and TMS in this population. This review underscores the importance of integrating neuroimaging findings to enhance understanding and treatment of AD.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Authors. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by- nc/4.0/). |
Keywords: | Adolescent depression; Brain connectivity; Neuroimaging; Research Domain Criteria (RDoC); Humans; Adolescent; Neuroimaging; Magnetic Resonance Imaging; Brain; Nerve Net; Depression |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield) |
Date Deposited: | 03 Oct 2025 08:16 |
Last Modified: | 03 Oct 2025 08:16 |
Status: | Published |
Publisher: | Elsevier BV |
Refereed: | Yes |
Identification Number: | 10.1016/j.pscychresns.2024.111917 |
Related URLs: | |
Sustainable Development Goals: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:232400 |