Abugable, A.A., Antar, S. orcid.org/0000-0001-6091-2835 and El-Khamisy, S.F. orcid.org/0000-0001-6781-3477 (2024) Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools. DNA Repair, 135. 103629. ISSN: 1568-7864
Abstract
Cells are constantly exposed to various sources of DNA damage that pose a threat to their genomic integrity. One of the most common types of DNA breaks are single-strand breaks (SSBs). Mutations in the repair proteins that are important for repairing SSBs have been reported in several neurological disorders. While several tools have been utilised to investigate SSBs in cells, it was only through recent advances in genomics that we are now beginning to understand the architecture of the non-random distribution of SSBs and their impact on key cellular processes such as transcription and epigenetic remodelling. Here, we discuss our current understanding of the genome-wide distribution of SSBs, their link to neurological disorders and summarise recent technologies to investigate SSBs at the genomic level.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | Cancer; DNA repair; Genomics; Neurodegeneration; SSBR; Humans; DNA Breaks, Single-Stranded; DNA Repair; DNA Damage; Nervous System Diseases; Genomics |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield) The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) |
Funding Information: | Funder Grant number WELLCOME TRUST (THE) 103844/Z/14/Z MEDICAL RESEARCH COUNCIL MR/Y000021/1 |
Date Deposited: | 03 Oct 2025 11:15 |
Last Modified: | 03 Oct 2025 11:15 |
Status: | Published |
Publisher: | Elsevier BV |
Refereed: | Yes |
Identification Number: | 10.1016/j.dnarep.2024.103629 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:232379 |