Adeno-associated virus-based rescue of Myo7a expression restores hair-cell function and improves hearing thresholds in a USH1B mouse strain

Amariutei, A.E. orcid.org/0000-0001-5803-1166, Webb, S., Carlton, A.J. orcid.org/0000-0002-1054-3901 et al. (10 more authors) (2025) Adeno-associated virus-based rescue of Myo7a expression restores hair-cell function and improves hearing thresholds in a USH1B mouse strain. The Journal of Physiology. ISSN: 0022-3751

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Item Type: Article
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© 2025 The Author(s). This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/

Keywords: cochlea; deafness; gene-based therapy; hair cell; ion channels; mechanoelectrical transduction; myosin motor; ribbon synapses
Dates:
  • Submitted: 18 June 2025
  • Accepted: 28 August 2025
  • Published (online): 27 September 2025
  • Published: 27 September 2025
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield)
Date Deposited: 29 Sep 2025 14:23
Last Modified: 29 Sep 2025 14:23
Status: Published online
Publisher: Wiley
Refereed: Yes
Identification Number: 10.1113/jp289526
Open Archives Initiative ID (OAI ID):

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