Mutations on the surface of HDAC1 reveal molecular determinants of specific complex assembly and their requirement for gene regulation

Alshehri, A., Baker, I.-M., English, D.M. et al. (4 more authors) (2025) Mutations on the surface of HDAC1 reveal molecular determinants of specific complex assembly and their requirement for gene regulation. Nucleic Acids Research, 53 (17). gkaf918. ISSN: 0305-1048

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Item Type: Article
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© The Author(s) 2025. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords: Histone Deacetylase 1; Animals; Mice; Repressor Proteins; Sin3 Histone Deacetylase and Corepressor Complex; Histone Deacetylase 2; Mutation; Histone Deacetylases; Gene Expression Regulation; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Acetylation; Protein Binding; Trans-Activators; Co-Repressor Proteins; Histones; Humans; Mouse Embryonic Stem Cells; Models, Molecular
Dates:
  • Submitted: 25 March 2025
  • Accepted: 20 August 2025
  • Published (online): 17 September 2025
  • Published: 23 September 2025
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield)
Funding Information:
Funder
Grant number
Biotechnology and Biological Sciences Research Council
BB/P021689/1
MEDICAL RESEARCH COUNCIL
MR/W00190X/1
MEDICAL RESEARCH COUNCIL
MR/X012220/1
WELLCOME TRUST (THE)
222493/Z/21/Z
Depositing User: Symplectic Sheffield
Date Deposited: 25 Sep 2025 14:05
Last Modified: 25 Sep 2025 14:05
Status: Published
Publisher: Oxford University Press (OUP)
Refereed: Yes
Identification Number: 10.1093/nar/gkaf918
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