Mendelian randomization study with clinical follow‐up links metabolites to risk and severity of pulmonary arterial hypertension

Alhathli, E. orcid.org/0009-0008-2147-9715, Julian, T. orcid.org/0000-0002-5488-5620, Girach, Z.U.A. et al. (8 more authors) (2024) Mendelian randomization study with clinical follow‐up links metabolites to risk and severity of pulmonary arterial hypertension. Journal of the American Heart Association, 13 (6). e032256. ISSN: 2047-9980

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Item Type: Article
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© 2024 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/

Keywords: Mendelian randomization; homostachydrine; metabolome; pulmonary arterial hypertension; serine; Humans; Pulmonary Arterial Hypertension; Genome-Wide Association Study; Mendelian Randomization Analysis; Follow-Up Studies; Familial Primary Pulmonary Hypertension; Serine
Dates:
  • Submitted: 21 August 2023
  • Accepted: 18 October 2023
  • Published (online): 8 March 2024
  • Published: 19 March 2024
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield)
Funding Information:
Funder
Grant number
MEDICAL RESEARCH COUNCIL
MR/K020919/1
BRITISH HEART FOUNDATION
FS/18/13/33281
WELLCOME TRUST (THE)
216596/Z/19/Z
BRITISH HEART FOUNDATION
FS/18/52/33808
Depositing User: Symplectic Sheffield
Date Deposited: 19 Sep 2025 10:14
Last Modified: 19 Sep 2025 10:14
Status: Published
Publisher: Ovid Technologies (Wolters Kluwer Health)
Refereed: Yes
Identification Number: 10.1161/jaha.123.032256
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Open Archives Initiative ID (OAI ID):

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