RAPTOR: Randomised Controlled Trial of PENTOCLO (pentoxifylline-tocopherol-clodronate) in Mandibular Osteoradionecrosis—study protocol for an open-label phase II randomised controlled superiority trial

Shaw, R., Knight, R., Basoglu, A. et al. (12 more authors) (2025) RAPTOR: Randomised Controlled Trial of PENTOCLO (pentoxifylline-tocopherol-clodronate) in Mandibular Osteoradionecrosis—study protocol for an open-label phase II randomised controlled superiority trial. Trials, 26 (1). 254. ISSN: 1745-6215

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • Shaw, R.
  • Knight, R.
  • Basoglu, A.
  • Bajwa, M.
  • Perry, J.
  • Kanatas, A. ORCID logo https://orcid.org/0000-0003-2025-748X
  • Fedele, S.
  • Killen, V.
  • Tangney, R.
  • Butterworth, C.
  • McCaul, J.
  • Dhanda, J.
  • Patel, V.
  • Evans, M.
  • Jackson, R.
Copyright, Publisher and Additional Information:

© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Keywords: Mandible, Osteoradionecrosis, Radiotherapy, Head and neck, Cancer, PENTOCLO, Pentoxifylline, Tocopherol, Sodium clodronate, Clinical trial
Dates:
  • Accepted: 2 July 2025
  • Published (online): 24 July 2025
  • Published: 24 July 2025
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > School of Dentistry Visitors (Leeds)
Depositing User: Symplectic Publications
Date Deposited: 07 Aug 2025 10:37
Last Modified: 07 Aug 2025 15:16
Published Version: https://trialsjournal.biomedcentral.com/articles/1...
Status: Published
Publisher: Springer Nature
Identification Number: 10.1186/s13063-025-08966-9
Related URLs:
Open Archives Initiative ID (OAI ID):

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