Otta, M. orcid.org/0000-0002-8062-1354, Zając, K. orcid.org/0000-0003-1393-8236, Malawski, M. orcid.org/0000-0001-6005-0243 et al. (4 more authors) (2025) Towards sensitivity analysis: 3D venous modelling in the lower limb. In: Paszynski, M., Barnard, A.S. and Zhang, Y.J., (eds.) Computational Science – ICCS 2025 Workshops. ICCS 2025 Workshops: 25th International Conference, 07-09 Jul 2025, Singapore. Lecture Notes in Computer Science, 15908 . Springer Nature Switzerland , pp. 98-112. ISBN: 9783031975561 ISSN: 0302-9743 EISSN: 1611-3349
Abstract
Deep vein thrombosis (DVT) of the lower extremity frequently leads to long-term complications known as post-thrombotic syndrome (PTS). The current clinical workflow for DVT and PTS treatment lacks sufficient evidence. The significance of the variation in the venous anatomy is yet to be understood. We report an analysis of a set of idealised 3D geometries of iliac vein unification to assess the importance of shape variability, inflow conditions, and viscosity on local haemodynamics - specifically on the wall shear stress metrics. Regions of low wall shear stress and high oscillating shear index have been associated with prothrombotic effects on the walls of blood vessels. A detailed steady state analysis focused on the wall shear stress distributions below three thresholds (<0.15Pa,<0.10Pa<0.05[Pa]). The preliminary work in the transient state focused on the oscillating shear index above three thresholds (>0.25,>0.35,>0.45). We found that all the variations implemented had an effect on the size and shape of the absolute vein wall area subject to the shear metrics of choice under the assumed flow conditions. The results obtained in this research will serve as a basis for the interpretation of patient-specific geometries of the iliac vein unification affected by deep vein thrombosis.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Editors: |
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Copyright, Publisher and Additional Information: | © 2025 The Authors. Except as otherwise noted, this author-accepted version of a proceedings paper published in Computational Science – ICCS 2025 Workshops is made available via the University of Sheffield Research Publications and Copyright Policy under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ |
Keywords: | deep vein thrombosis; post-thrombotic syndrome; venous modelling; CFD; sensitivity analysis |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Funding Information: | Funder Grant number EUROPEAN COMMISSION - HORIZON 2020 857533 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 31 Jul 2025 07:34 |
Last Modified: | 31 Jul 2025 07:34 |
Status: | Published |
Publisher: | Springer Nature Switzerland |
Series Name: | Lecture Notes in Computer Science |
Refereed: | Yes |
Identification Number: | 10.1007/978-3-031-97557-8_8 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:229877 |