Artemether and Euphorbia Factor L9 suppress kynurenine production through distinct effects on Tryptophan metabolism

This is a preprint and may not have undergone formal peer review

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Item Type:	Preprint
Authors/Creators:	Capatina, Alina (alc618@york.ac.uk) Czechowski, Tomasz (tomasz.czechowski@york.ac.uk) Plunkett, K Tonon, Thierry https://orcid.org/0000-0002-1454-6018 Kourtzelis, Ioannis https://orcid.org/0000-0003-3006-8885 Lichman, Benjamin R. https://orcid.org/0000-0002-0033-1120 Brackenbury, William https://orcid.org/0000-0001-6882-3351 Graham, Ian Alexander https://orcid.org/0000-0003-4007-1770 Lagos, Dimitris https://orcid.org/0000-0003-0637-281X
Keywords:	Tryptophan metabolism,immune checkpoints,natural products,IDO1,artemisinin,Euphorbia factors,breast cancer,drug screening,metabolomics
Dates:	Published: 4 June 2025
Institution:	The University of York
Academic Units:	The University of York > Faculty of Sciences (York) > Hull York Medical School (York) The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Sciences (York) > Biology (York) > Centre for Novel Agricultural Products (CNAP) (York) The University of York > Faculty of Sciences (York) > Biology (York) > Jack Birch Unit for Molecular Carcinogenesis (York)
Depositing User:	Pure (York)
Date Deposited:	29 Jul 2025 23:09
Last Modified:	20 Sep 2025 02:31
Published Version:	https://doi.org/10.1101/2025.06.02.657401
Status:	Published
Publisher:	biorxiv
Identification Number:	10.1101/2025.06.02.657401
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:229800

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