HER2-enriched subtype and novel molecular subgroups drive aromatase inhibitor resistance and an increased risk of relapse in early ER+/HER2+ breast cancer

Bergamino, M.A. orcid.org/0000-0002-1091-2711, López-Knowles, E. orcid.org/0000-0002-0893-3361, Morani, G. orcid.org/0000-0002-6385-3137 et al. (173 more authors) (2022) HER2-enriched subtype and novel molecular subgroups drive aromatase inhibitor resistance and an increased risk of relapse in early ER+/HER2+ breast cancer. eBioMedicine, 83. 104205. ISSN 2352-3964

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • Bergamino, M.A. ORCID logo https://orcid.org/0000-0002-1091-2711
  • López-Knowles, E. ORCID logo https://orcid.org/0000-0002-0893-3361
  • Morani, G. ORCID logo https://orcid.org/0000-0002-6385-3137
  • Tovey, H.
  • Kilburn, L.
  • Schuster, E.F. ORCID logo https://orcid.org/0000-0001-5076-2810
  • Alataki, A. ORCID logo https://orcid.org/0000-0002-9491-7033
  • Hills, M.
  • Xiao, H.
  • Holcombe, C.
  • Skene, A.
  • Robertson, J.F.
  • Smith, I.E.
  • Bliss, J.M.
  • Dowsett, M.
  • Cheang, M.C.U. ORCID logo https://orcid.org/0000-0001-5718-2501
  • Evans, A.
  • Ball, A.
  • Johri, A.
  • Nejim, A.
  • Jones, A.
  • Corder, A.
  • Thorne, A.
  • Anand, A.
  • Chakrabarti, A.
  • Robinson, A.
  • Skene, A.
  • Modi, A.
  • Patel, A.
  • Kothari, A.
  • McFall, B.
  • Mortimer, C.
  • Lee, C.
  • Chan, C.
  • Abson, C.
  • Holcombe, C.
  • Hinton, C.
  • Hollywood, C.
  • Murphy, C.
  • Crowley, C.
  • Harding-Mackean, C.
  • Griffith, C.
  • Lewanski, C.
  • Rea, D.
  • Hwang, D.
  • Crawford, D.
  • Thekkinkattil, D.
  • Ferguson, D.
  • Adamson, D.
  • Wheatley, D.
  • Ravichandran, D.
  • Babu, E.
  • Hyett, E.
  • Ashkanani, F.
  • Hoar, F.
  • Kenny, F.
  • Dyke, G.
  • Sparrow, G.
  • Gilbert
  • Cunnick, G.
  • Algurafi, H.
  • Sweetland, H.
  • Prof, H.-D.
  • Hamed, H.
  • Smith, I.
  • Laidlaw, I.
  • Khattak, I.
  • Newby, J.
  • Rees-Lee, J.
  • Kokan, J.
  • Barrett, J.
  • Naik, J.D.
  • Vaidya, J.
  • Forrest, J.
  • Parmar, J.
  • Adams, J.
  • Fox, J.
  • Roberts, J.
  • Dawson, J.
  • Doughty, J.
  • Donnelly, J.
  • Dunn, K.
  • Chin, K.
  • Horgan, K.
  • Thakur, K.
  • Barthelmes, L.
  • Wyld, L. ORCID logo https://orcid.org/0000-0002-4046-5940
  • Bhattacharyya, M.
  • Hadaki, M.
  • Kishore, M.
  • Ornstein, M.
  • Bramley, M.
  • Bews-Hair, M.
  • Parton, M.
  • Sibbering, M.
  • Kissin, M.
  • Churn, M.
  • Hogg, M.
  • Quigley, M.
  • Hatton, M. ORCID logo https://orcid.org/0000-0003-2778-7926
  • Winter, M. ORCID logo https://orcid.org/0000-0001-6192-9874
  • Adelekan, M.
  • Shere, M.
  • Carr, M.
  • Williams, M.
  • Absar, M.
  • Sharif, M.
  • Kelleher, M.
  • Walji, N.
  • Williams, N.
  • Gallegos, N.
  • Bundred, N.
  • Hatcher, O.
  • Crellin, P.
  • Crane, P.
  • Donnelly, P.
  • Kneeshaw, P.
  • Walker, P.
  • Sinha, P.
  • Bhaskar, P.
  • Soulsby, R.
  • Todd, R.
  • Vidya, R.
  • Mehra, R.
  • Prasad, R.
  • Cutress, R.
  • Sharma, R.
  • Roylance, R.
  • Goranova, R.
  • Salman, R.R.
  • Bonom, R.
  • Johnson, R.
  • Sutton, R.
  • Linforth, R.
  • Coleman, R.
  • Grieve, R.
  • Leonard, R.
  • Reichert, R.
  • Kennedy, R.
  • Agarwal, R.
  • Allerton, R.
  • Burcombe, R.
  • Davis, R.
  • Narayanan, S.
  • Chandrasekharan, S.
  • Vesty, S.
  • Seetharam, S.
  • Ledwidge, S.
  • Iqbal, S.
  • Wahee, S.
  • Silva, S.
  • Pain, S.
  • Holt, S.
  • Thomson, S.
  • Smith, S.
  • Ellenbogen, S.
  • Holt, S.
  • Laws, S.
  • Chan, S.
  • Johnston, S.
  • Holt, S.
  • Thrush, S.
  • McIntosh, S.
  • Chatterjee, S.
  • Cleator, S.
  • Usman, T.
  • Johnson, T.
  • Kovacs, T.
  • Irvine, T.
  • Barthkur, U.
  • Pope, V.
  • Brown, V.A.
  • Muralikrishna, V.
  • Samra, W.
  • Maxwell, W.
  • Winters, Z.
Copyright, Publisher and Additional Information:

2022 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Keywords: Aromatase inhibitors; Breast cancer; HER2+; HER2-Enriched subtype; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Clinical Trials as Topic; Female; Humans; Ki-67 Antigen; Neoplasm Recurrence, Local; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone
Dates:
  • Accepted: 22 July 2022
  • Published (online): 16 August 2022
  • Published: September 2022
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Depositing User: Symplectic Sheffield
Date Deposited: 14 Jul 2025 11:44
Last Modified: 14 Jul 2025 11:44
Status: Published
Publisher: Elsevier BV
Refereed: Yes
Identification Number: 10.1016/j.ebiom.2022.104205
Related URLs:
Open Archives Initiative ID (OAI ID):

Export

Statistics


CORE (COnnecting REpositories)