Asare, E. orcid.org/0009-0004-7925-5301, Azimi, B., Vasili, E. et al. (6 more authors) (2025) Electrospun fibers of polyhydroxyalkanoate/bacterial cellulose blends and their role in nerve tissue engineering. Macromolecular Materials and Engineering. e00074. ISSN 1438-7492
Abstract
Multimaterial blends are crucial for developing scaffolds for tissue engineering. In this study, novel blend electrospun nanofibers are created by combining short-chain length polyhydroxyalkanoates (SCL-PHAs), medium-chain length polyhydroxyalkanoates (MCL-PHAs), and bacterial cellulose (BC) using the electrospinning technique. The resulting fibrous materials are characterized for their thermal properties, morphology, and cytocompatibility with NG108-15 neuronal cells. The fabricated blend nanofibers demonstrate good cytocompatibility, as indicated by trends in cell viability and neurite outgrowth in NG108-15 cells. Importantly, the inclusion of BC in the blend significantly improves the thermal stability of the polymer matrix, as confirmed by thermogravimetric analysis. This study introduces the concept of environmentally friendly and multifunctional materials, highlighting their potential for diverse applications in various scientific disciplines and industries, particularly in the field of nerve tissue engineering.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2025 The Author(s). Macromolecular Materials and Engineering published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | bacterial cellulose (BC); nanofibers; polyhydroxyalkanoates; tissue engineering |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > School of Chemical, Materials and Biological Engineering |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 03 Jun 2025 14:10 |
Last Modified: | 03 Jun 2025 14:10 |
Status: | Published online |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/mame.202500074 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:227327 |