FUT8 is a critical driver of prostate tumour growth and can be targeted using fucosylation inhibitors

Bastian, K., Orozco‐Moreno, M., Thomas, H. et al. (26 more authors) (2025) FUT8 is a critical driver of prostate tumour growth and can be targeted using fucosylation inhibitors. Cancer Medicine, 14 (10). e70959. ISSN 2045-7634

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • Bastian, K.
  • Orozco‐Moreno, M.
  • Thomas, H.
  • Hodgson, K.
  • Visser, E.A.
  • Rossing, E.
  • Pijnenborg, J.F.A.
  • Eerden, N.
  • Wilson, L.
  • Saravannan, H.
  • Hanley, O.
  • Grimsley, G.
  • Frame, F.
  • Peng, Z.
  • Knight, B.
  • McCullagh, P.
  • McGrath, J.
  • Crundwell, M.
  • Harries, L.
  • Maitland, N.J.
  • Heer, R.
  • Wang, N. ORCID logo https://orcid.org/0000-0002-2663-7515
  • Goddard‐Borger, E.D.
  • Guerrero, R.H.
  • Boltje, T.J.
  • Drake, R.R.
  • Scott, E.
  • Elliott, D.J.
  • Munkley, J. ORCID logo https://orcid.org/0000-0002-8631-4531
Copyright, Publisher and Additional Information:

© 2025 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords: Cell Line, Tumor; Animals; Humans; Mice; Prostatic Neoplasms; Fucosyltransferases; Fucose; Polysaccharides; Enzyme Inhibitors; Xenograft Model Antitumor Assays; Cell Proliferation; Cell Movement; Gene Expression Regulation, Neoplastic; Glycosylation; Male
Dates:
  • Accepted: 29 April 2025
  • Published (online): 19 May 2025
  • Published: May 2025
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Funding Information:
Funder
Grant number
PROSTATE CANCER UK
RIA21-ST2-006
Depositing User: Symplectic Sheffield
Date Deposited: 27 May 2025 09:45
Last Modified: 27 May 2025 09:45
Published Version: https://doi.org/10.1002/cam4.70959
Status: Published
Publisher: Wiley
Refereed: Yes
Identification Number: 10.1002/cam4.70959
Open Archives Initiative ID (OAI ID):

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