Reid, L. and Webster, R.K. orcid.org/0000-0002-5136-1098 (2025) Exploring the relationship between medicine related beliefs and side-effect experience among White oral contraceptive users in the UK. Perspectives on Sexual and Reproductive Health. ISSN 1538-6341
Abstract
Objectives
Side-effects are often central to the decision to discontinue oral contraceptives. However, many oral contraceptive side-effects may be the result of a psychological nocebo effect. In this preliminary study, we investigate whether correlates of nocebo effects are associated with oral contraceptive side-effect experience.
Design
An exploratory online cross-sectional survey of 275 female, predominantly young, White respondents was conducted. Associations between psychological factors previously implicated in nocebo responses (beliefs about medicines, perceived sensitivity to medicines, side-effect expectations, medicine information seeking, anxiety and trust in medicines), and oral contraceptive side-effect experience were assessed using regression analyses.
Results
Increased side-effect expectations, stronger beliefs that medicines cause harm and are overused, increased perceived sensitivity to medicines, and decreased trust in medicine development were associated with increased attribution of symptoms to the oral contraceptive. Higher side-effect attribution scores were also associated with discontinued oral contraceptive use.
Conclusion
These preliminary findings demonstrate a potential role that nocebo-related factors may have in impacting oral contraceptive side-effect experience. Importantly, these factors are amenable to psychological interventions which could be employed to reduce oral contraceptive side-effect experience and, as a result, unnecessary discontinuation. Future research must first assess such relationships using a prospective design to confirm the direction of the associations identified using more diverse samples of oral contraceptive users to increase the generalisability of findings.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2025 The Author(s). Perspectives on Sexual and Reproductive Health published by Wiley Periodicals LLC on behalf of University of Ottawa. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Oral contraceptives; side effects; nocebo effect; medicine beliefs; discontinuation |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 22 May 2025 15:35 |
Last Modified: | 27 May 2025 09:51 |
Status: | Published online |
Publisher: | University of Ottawa / Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/psrh.70012 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:226760 |