Rowen, D., Carlton, J., McDool, E. orcid.org/0000-0002-3530-7921 et al. (83 more authors) (2025) Psychometric performance of a new condition-specific preference-weighted measure, VILL-UI, and EQ-5D-5L in patients with age-related macular degeneration: A MACUSTAR Study Report. Value in Health. ISSN 1098-3015
Abstract
Aims
The Vision Impairment in Low Luminance-Utility Index (VILL-UI) is a novel preference-weighted measure for use in patients with age-related macular degeneration (AMD). No evidence exists on its psychometric performance, nor its performance in comparison to generic preference-weighted measure, EQ-5D-5L commonly used in economic evaluation. This study compares the psychometric performance of VILL-UI and EQ-5D-5L in patients with AMD.
Methods
Assessments of feasibility, convergent/divergent validity and known-group validity of VILL-UI and EQ-5D-5L are undertaken using MACUSTAR data at baseline, 12, 24 and 36 months. Analyses are undertaken separately using UK and German preference weights for both measures.
Results
The sample with complete responses (n=586) had mean age 71.9 years (standard deviation 6.9), 65.2% women, with predominantly intermediate AMD (87.2%). VILL-UI and EQ-5D-5L are feasible for completion, though VILL-UI has fewer usable responses due to its response options (baseline 89% vs 100%). EQ-5D-5L has high ceiling effects, with around one third of participants reporting the best health state compared to under 8% for VILL-UI. Convergent validity between EQ-5D-5L and VILL-UI utilities and dimensions where a relationship is expected is low, with divergent validity demonstrated where expected. VILL-UI detected statistically significant differences in known-groups for visual acuity, visual function and AMD stage across most timepoints, with little evidence of known-group validity for EQ-5D-5L.
Conclusions
VILL-UI is appropriate for use in future AMD studies to inform economic evaluation. VILL-UI has superior performance to EQ-5D-5L for known-group validity and has fewer ceiling effects, but has fewer usable responses.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2025 The Authors. Except as otherwise noted, this author-accepted version of a journal article published in Value in Health is made available via the University of Sheffield Research Publications and Copyright Policy under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ |
Keywords: | age-related macular degeneration; EQ-5D-5L; VILL-UI; psychometrics |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Funding Information: | Funder Grant number EUROPEAN COMMISSION - HORIZON 2020 116076 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 09 May 2025 13:42 |
Last Modified: | 09 May 2025 13:42 |
Status: | Published online |
Publisher: | Elsevier BV |
Refereed: | Yes |
Identification Number: | 10.1016/j.jval.2025.04.2155 |
Related URLs: | |
Sustainable Development Goals: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:226494 |
Downloads
Filename: Psych comp VILL-UI EQ-5D-5L Accepted.pdf
Licence: CC-BY 4.0
Filename: VILL-UI and 5L Supplementary Materials REV 210325.pdf
Licence: CC-BY 4.0