Lai, W.-F. orcid.org/0000-0003-0585-6396 (2025) Design and Applications of Polymersomes for Oral Drug Administration. ACS Applied Materials & Interfaces, 17 (21). pp. 30423-30435. ISSN 1944-8244
Abstract
Polymersomes are nanostructures consisting of a hollow aqueous compartment enclosed by a coating of amphiphilic block copolymers. Owing to the entangled nature of their membrane, polymersomes exhibit higher mechanical stability than some other extensively studied nanostructures such as liposomes. This also enables the properties of the polymersome membrane to be more easily tuned to meet practical needs, making polymersomes promising carriers for drug delivery. Since the turn of the last century, the use of polymersomes has been exploited in diverse areas, ranging from protein therapy to medical imaging. Yet, discussions exploring the opportunities and challenges of the development of polymersomes for oral drug administration have been scant. This review addresses this gap by offering a snapshot of the current advances in the design, fabrication, and use of polymersomes as oral drug carriers. It is hoped that this review will not only highlight the practical potential of polymersomes for oral drug administration but will also shed light on the challenges determining the wider clinical potential of polymersomes in the forthcoming decades.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2025 The Author. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | polymersomes, block copolymers, colloidal behavior, drug delivery, oral administration, controlled release, amphiphilicity |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 May 2025 09:38 |
Last Modified: | 12 Jun 2025 11:50 |
Status: | Published |
Publisher: | American Chemical Society |
Identification Number: | 10.1021/acsami.5c04658 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:226352 |
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