Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies

Smith, C.E.L., Streets, A.J. orcid.org/0000-0002-4328-044X, Lake, A.V.R. orcid.org/0000-0002-6341-8661 et al. (14 more authors) (2025) Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies. Communications Medicine, 5. 129. ISSN 2730-664X

Abstract

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Item Type: Article
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© 2025 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords: High-throughput screening; Polycystic kidney disease; RNAi
Dates:
  • Accepted: 4 April 2025
  • Published (online): 19 April 2025
  • Published: 19 April 2025
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Funding Information:
Funder
Grant number
KIDNEY RESEARCH UK
PKD_RP_005_20211124
Depositing User: Symplectic Sheffield
Date Deposited: 24 Apr 2025 08:41
Last Modified: 24 Apr 2025 08:41
Published Version: https://doi.org/10.1038/s43856-025-00847-1
Status: Published
Publisher: Springer Science and Business Media LLC
Refereed: Yes
Identification Number: 10.1038/s43856-025-00847-1
Open Archives Initiative ID (OAI ID):

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