Fulgencio, Sofia, Scaccaglia, Mirco and Frei, Angelo orcid.org/0000-0001-6169-2491 (2024) Exploration of Rhenium Bisquinoline Tricarbonyl Complexes for their Antibacterial Properties. Chembiochem. e202400435. ISSN 1439-7633
Abstract
Metal complexes have emerged as a promising source for novel classes of antibacterial agents to combat the rise of antimicrobial resistance around the world. In the exploration of the transition metal chemical space for novel metalloantibiotics, the rhenium tricarbonyl moiety has been identified as a promising scaffold. Here we have prepared eight novel rhenium bisquinoline tricarbonyl complexes and explored their antibacterial properties. Significant activity against both Gram-positive and Gram-negative bacteria was observed. However, all complexes also showed significant toxicity against human cells, putting into question the prospects of this specific rhenium compound class as metalloantibiotics. To better understand their biological effects, we conduct the first mode of action studies on rhenium bisquinoline complexes and show that they are able to form pores through bacterial membranes. Their straight-forward synthesis and tuneability suggests that further optimisation of this compound class could lead to compounds with enhanced bacterial specificity.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Publisher Copyright: © 2024 The Authors. ChemBioChem published by Wiley-VCH GmbH. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 28 Mar 2025 14:10 |
Last Modified: | 28 Mar 2025 14:10 |
Published Version: | https://doi.org/10.1002/cbic.202400435 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/cbic.202400435 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:224989 |
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Description: ChemBioChem - 2024 - Fulgencio - Exploration of Rhenium Bisquinoline Tricarbonyl Complexes for their Antibacterial
Licence: CC-BY 2.5