Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within a cohort, with economic evaluation, process evaluation and qualitative sub-study, to explore the natural history of LARS and compare transanal irrigation and sacral neuromodulation to optimised conservative management for people with major LARS following a high or low anterior resection for colorectal cancer

Croft, J. orcid.org/0000-0001-7586-3394, Farrow, E., Coxon-Meggy, A.H. et al. (22 more authors) (2025) Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within a cohort, with economic evaluation, process evaluation and qualitative sub-study, to explore the natural history of LARS and compare transanal irrigation and sacral neuromodulation to optimised conservative management for people with major LARS following a high or low anterior resection for colorectal cancer. BMJ Open, 15 (2). e092612. ISSN 2044-6055

Abstract

Metadata

Item Type: Article
Authors/Creators:
Copyright, Publisher and Additional Information:

© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/ licenses/by/4.0/.

Dates:
  • Published: March 2025
  • Published (online): 3 February 2025
  • Accepted: 29 November 2024
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds)
Funding Information:
Funder
Grant number
NIHR National Inst Health Research
8201
Depositing User: Symplectic Publications
Date Deposited: 28 Mar 2025 14:14
Last Modified: 28 Mar 2025 14:16
Published Version: https://bmjopen.bmj.com/content/15/2/e092612
Status: Published
Publisher: BMJ
Identification Number: 10.1136/bmjopen-2024-092612
Related URLs:
Open Archives Initiative ID (OAI ID):

Export

Statistics