Increased primary breast tumor expression of CD73 is associated with development of bone metastases and is a potential biomarker for adjuvant bisphosphonate use

Petruk, N., Wood, S.L., Gregory, W. et al. (7 more authors) (2025) Increased primary breast tumor expression of CD73 is associated with development of bone metastases and is a potential biomarker for adjuvant bisphosphonate use. Scientific Reports, 15 (1). 9449. ISSN 2045-2322

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Item Type: Article
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© The Author(s) 2025. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Keywords: Bone metastases; Breast cancer; CD73; TMA; Humans; Breast Neoplasms; Female; Bone Neoplasms; 5'-Nucleotidase; Biomarkers, Tumor; Diphosphonates; Middle Aged; GPI-Linked Proteins; Zoledronic Acid; Aged; Prognosis; Chemotherapy, Adjuvant; Bone Density Conservation Agents
Dates:
  • Published: 19 March 2025
  • Published (online): 19 March 2025
  • Accepted: 3 March 2025
  • Submitted: 25 November 2024
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Depositing User: Symplectic Sheffield
Date Deposited: 27 Mar 2025 08:19
Last Modified: 27 Mar 2025 08:19
Status: Published
Publisher: Springer Science and Business Media LLC
Refereed: Yes
Identification Number: 10.1038/s41598-025-92841-9
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