Iqbal, Naeem, Wolstenholme-Hogg, Amy, Gompels, James R. et al. (1 more author) (2025) Quantitative Characterization of Organosilane Monolayers by Oxidative Dissociation of Monolayer Molecules. Analytical Chemistry. ISSN 0003-2700
Abstract
Self-assembled organosilane monolayers on silica surfaces find many applications; however, their structural characterization is challenging. We found that organic molecules in these monolayers can be dissociated from the surface by cleaving C-Si bonds under mild conditions of Fleming-Tamao oxidation. Once removed from the surface, the monolayer molecules could be isolated, purified, and analyzed in solution using conventional analytical techniques including NMR and GC-MS. This method enables efficient cleavage of different organic molecules attached to silica supports (e.g., in mixed monolayers) and is tolerant to a wide range of functional groups. Organic monolayers can be dissociated from a range of silica substrates, including silica nanoparticles, silica gel, flat glass slides, and related inorganic oxides, such as alumina or titania.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Publisher Copyright: © 2025 The Authors. Published by American Chemical Society. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 18 Mar 2025 15:50 |
Last Modified: | 18 Mar 2025 15:50 |
Published Version: | https://doi.org/10.1021/acs.analchem.4c06937 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1021/acs.analchem.4c06937 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:224591 |
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