ImmuneLENS characterizes systemic immune dysregulation in aging and cancer

Bentham, R., Jones, T.P. orcid.org/0000-0003-2748-0780, Black, J.R.M. orcid.org/0000-0001-5598-7752 et al. (327 more authors) (2025) ImmuneLENS characterizes systemic immune dysregulation in aging and cancer. Nature Genetics, 57. pp. 694-705. ISSN 1061-4036

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • Bentham, R.
  • Jones, T.P. ORCID logo https://orcid.org/0000-0003-2748-0780
  • Black, J.R.M. ORCID logo https://orcid.org/0000-0001-5598-7752
  • Martinez-Ruiz, C. ORCID logo https://orcid.org/0000-0002-4817-0565
  • Dietzen, M. ORCID logo https://orcid.org/0000-0002-6853-7563
  • Litovchenko, M.
  • Thol, K. ORCID logo https://orcid.org/0000-0002-4624-118X
  • Watkins, T.B.K.
  • Bailey, C.
  • Pich, O. ORCID logo https://orcid.org/0000-0002-1956-1882
  • Zhang, Z.
  • Van Loo, P. ORCID logo https://orcid.org/0000-0003-0292-1949
  • Jamal-Hanjani, M.
  • Martínez-Ruiz, C.
  • Van Loo, P.
  • Black, J.R.M.
  • Karasaki, T.
  • Bunkum, A.
  • Hessey, S.
  • Liu, W.K.
  • Birkbak, N.J.
  • Frankell, A.M.
  • Huebner, A.
  • Puttick, C.
  • Hiley, C.T.
  • Moore, D.A.
  • Biswas, D.
  • Lim, E.L.
  • Grigoriadis, K.
  • Bakir, M.A.
  • Lucas, O.
  • Vendramin, R.
  • Ward, S.
  • Harries, S.
  • Zaccaria, S.
  • Zaidi, R.
  • Patruno, L.
  • Karagianni, D.
  • Quezada, S.A.
  • Bola, S.K.
  • Forster, M.D.
  • Lee, S.M.
  • Richard, C.
  • Naceur-Lombardelli, C.
  • Gimeno-Valiente, F.
  • Thakkar, K.
  • Sivakumar, M.
  • Kanu, N.
  • Usaite, I.
  • Saghafinia, S.
  • Veeriah, S.
  • Vanloo, S.
  • Toncheva, A.
  • Prymas, P.
  • Mussa, B.
  • Magala, M.
  • Keene, E.
  • Leung, M.M.
  • Wilson, G.A.
  • Rosenthal, R.
  • Rowan, A.
  • Lee, C.
  • Colliver, E.
  • Enfield, K.S.S.
  • Angelova, M.
  • Murphy, C.
  • Zagorulya, M.
  • Marafioti, T.
  • Borg, E.
  • Falzon, M.
  • Khiroya, R.
  • Wong, Y.N.S.
  • Hoogenboom, E.M.
  • Monk, F.
  • Holding, J.W.
  • Choudhary, J.
  • Bhakhri, K.
  • Gorman, P.
  • Stephens, R.C.M.
  • Pisciella, M.C.
  • Bandula, S.
  • Nicod, J.
  • Dwornik, A.
  • Karamani, A.
  • Chain, B.
  • Pearce, D.R.
  • Stavrou, G.
  • Mastrokalos, G.-T.
  • Lowe, H.L.
  • Reading, J.L.
  • Hartley, J.A.
  • Selvaraju, K.
  • Ensell, L.
  • Shah, M.
  • Pawlik, P.
  • Gamble, S.
  • Ung, S.K.A.
  • Spanswick, V.
  • Wu, Y.
  • Lester, J.F.
  • Dulloo, S.
  • Fennell, D.A.
  • Bajaj, A.
  • Nakas, A.
  • Sodha-Ramdeen, A.
  • Tufail, M.
  • Scotland, M.
  • Boyles, R.
  • Rathinam, S.
  • Wilson, C.
  • Matharu, G.
  • Shaw, J.A.
  • Boleti, E.
  • Cheyne, H.
  • Khalil, M.
  • Richardson, S.
  • Cruickshank, T.
  • Price, G.
  • Kerr, K.M.
  • Benafif, S.
  • Papadatos-Pastos, D.
  • Wilson, J.
  • Ahmad, T.
  • French, J.
  • Gilbert, K.
  • Naidu, B.
  • Patel, A.J.
  • Middleton, G.
  • Osman, A.
  • Sangha, M.
  • Langman, G.
  • Shackleford, H.
  • Djearaman, M.
  • Leek, A.
  • Hodgkinson, J.D.
  • Totton, N.
  • Crosbie, P.
  • Fontaine, E.
  • Granato, F.
  • Novasio, J.
  • Rammohan, K.
  • Joseph, L.
  • Bishop, P.
  • Joshi, V.
  • Waplington, S.
  • Atkin, A.
  • Brown, K.D.
  • Carter, M.
  • Chaturvedi, A.
  • Oliveira, P.
  • Lindsay, C.R.
  • Blackhall, F.H.
  • Summers, Y.
  • Krebs, M.G.
  • Paiva-Correia, A.
  • Tugwood, J.
  • Dive, C.
  • Aerts, H.J.W.L.
  • Schwarz, R.F.
  • Kaufmann, T.L.
  • Szallasi, Z.
  • Diossy, M.
  • Salgado, R.
  • Demeulemeester, J.
  • Castignani, C.
  • Beck, S.
  • Kassiotis, G.
  • Noorani, I.
  • Weeden, C.E.
  • Grönroos, E.
  • Goldman, J.
  • Escudero, M.
  • Hobson, P.
  • Boeing, S.
  • Denner, T.
  • Barbè, V.
  • Lu, W.-T.
  • Hill, W.
  • Naito, Y.
  • Sahai, E.
  • Ramsden, Z.
  • Nye, E.
  • Stone, R.K.
  • Rane, J.K.
  • Kittel, J.
  • Haase, K.
  • Koh, K.
  • Scott, R.
  • Peggs, K.S.
  • Veiga, C.
  • Royle, G.
  • Collins-Fekete, C.-A.
  • Fraioli, F.
  • Ashford, P.
  • Nair, A.
  • Procter, A.J.
  • Ahmed, A.
  • Taylor, M.N.
  • Lawrence, D.
  • Patrini, D.
  • Navani, N.
  • Thakrar, R.M.
  • Janes, S.M.
  • Kaplar, Z.
  • Hackshaw, A.
  • Pilotti, C.
  • Leslie, R.
  • Hacker, A.-M.
  • Smith, S.
  • Walker, A.
  • Grapa, A.
  • Zhang, H.
  • AbdulJabbar, K.
  • Pan, X.
  • Yuan, Y.
  • Chuter, D.
  • MacKenzie, M.
  • Chee, S.
  • Georg, P.
  • Alzetani, A.
  • Cave, J.
  • Lim, E.
  • Nicholson, A.G.
  • De Sousa, P.
  • Jordan, S.
  • Rice, A.
  • Raubenheimer, H.
  • Bhayani, H.
  • Ambrose, L.
  • Devaraj, A.
  • Chavan, H.
  • Begum, S.
  • Buderi, S.I.
  • Kaniu, D.
  • Malima, M.
  • Booth, S.
  • Fernandes, N.
  • Shah, P.
  • Proli, C.
  • Hewish, M.
  • Danson, S. ORCID logo https://orcid.org/0000-0002-3593-2890
  • Shackcloth, M.J.
  • Robinson, L.
  • Russell, P.
  • Blyth, K.G.
  • Kidd, A.
  • Dick, C.
  • Le Quesne, J.
  • Kirk, A.
  • Asif, M.
  • Bilancia, R.
  • Kostoulas, N.
  • Whiteley, J.
  • Thomas, M.
  • Ambrose, J.C.
  • Arumugam, P.
  • Baple, E.L.
  • Bleda, M.
  • Boardman-Pretty, F.
  • Boissiere, J.M.
  • Boustred, C.R.
  • Brittain, H.
  • Caulfield, M.J.
  • Chan, G.C.
  • Craig, C.E.H.
  • Daugherty, L.C.
  • de Burca, A.
  • Devereau, A.
  • Elgar, G.
  • Foulger, R.E.
  • Fowler, T.
  • Furió-Tarí, P.
  • Hackett, J.M.
  • Halai, D.
  • Hamblin, A.
  • Henderson, S.
  • Holman, J.E.
  • Hubbard, T.J.P.
  • Ibáñez, K.
  • Jackson, R.
  • Jones, L.J.
  • Kasperaviciute, D.
  • Kayikci, M.
  • Lahnstein, L.
  • Lawson, L.
  • Leigh, S.E.A.
  • Leong, I.U.S.
  • Lopez, F.J.
  • Maleady-Crowe, F.
  • Mason, J.
  • McDonagh, E.M.
  • Moutsianas, L.
  • Mueller, M.
  • Murugaesu, N.
  • Need, A.C.
  • Odhams, C.A.
  • Patch, C.
  • Perez-Gil, D.
  • Polychronopoulos, D.
  • Pullinger, J.
  • Rahim, T.
  • Rendon, A.
  • Riesgo-Ferreiro, P.
  • Rogers, T.
  • Ryten, M.
  • Savage, K.
  • Sawant, K.
  • Scott, R.H.
  • Siddiq, A.
  • Sieghart, A.
  • Smedley, D.
  • Smith, K.R.
  • Sosinsky, A.
  • Spooner, W.
  • Stevens, H.E.
  • Stuckey, A.
  • Sultana, R.
  • Thomas, E.R.A.
  • Thompson, S.R.
  • Tregidgo, C.
  • Tucci, A.
  • Walsh, E.
  • Watters, S.A.
  • Welland, M.J.
  • Williams, E.
  • Witkowska, K.
  • Wood, S.M.
  • Zarowiecki, M.
  • Swanton, C. ORCID logo https://orcid.org/0000-0002-4299-3018
  • McGranahan, N. ORCID logo https://orcid.org/0000-0001-9537-4045
Copyright, Publisher and Additional Information:

© The Author(s) 2025. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: TRACERx Consortium; Genomics England Consortium
Dates:
  • Published: March 2025
  • Published (online): 18 February 2025
  • Accepted: 10 January 2025
  • Submitted: 2 May 2023
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Depositing User: Symplectic Sheffield
Date Deposited: 07 Mar 2025 10:41
Last Modified: 18 Mar 2025 14:57
Status: Published
Publisher: Springer Science and Business Media LLC
Refereed: Yes
Identification Number: 10.1038/s41588-025-02086-5
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Sustainable Development Goals:
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