Treatment and rehabilitation of Long COVID:A scope of the literature. Update October 2024

• We identified 16 randomised controlled trials published between June and September 2024 that were focused on Long COVID treatment or rehabilitation. Across our ten reports produced to date, we have identified and assessed 156 trials published between January 2022 and September 2024. • Eight of the 16 trials focused on treating generalised or multiple symptoms of Long COVID. Three trials focused specifically on respiratory or cardiovascular function or physical fitness, two of which also had a focus on fatigue. One other trial focused specifically on treating fatigue. Two trials focused on treating persistent problems with the sense of smell or taste (olfactory/gustatory dysfunction) and two evaluated treatments for neuropsychological sequela. • Two trials were rated positively for 12 out of the 13 quality criteria that we assessed and three met 11 criteria. The remaining 11 trials gained a positive rating for between seven and ten criteria.