Dong, S., Yu, B., Yin, C. et al. (12 more authors) (2024) Associations between PM2.5 and its chemical constituents and blood pressure: a cross-sectional study. Journal of Hypertension, 42 (11). pp. 1897-1905. ISSN 0263-6352
Abstract
Objectives: To investigate the associations between PM2.5 and its chemical constituents with blood pressure (BP), assess effects across BP quantiles, and identify the key constituent elevating BP.
Methods: A total of 36 792 adults were included in the cross-sectional study, representing 25 districts/counties of southeast China. Quantile regression models were applied to estimate the associations of PM2.5 and its chemical constituents (ammonium [NH4+], nitrate [NO3−], sulfate [SO42−], black carbon [BC], organic matter [OM]) with systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean artery pressure (MAP). A weighted quantile sum (WQS) index was used to estimate the relative importance of each PM2.5 chemical constituent to the joint effect on BP.
Results: The adverse effects of each interquartile range (IQR) increase in PM2.5, NH4+, NO3−, SO42−, and BC on BP were found to be greater with elevated BP, especially when SBP exceeded 133 mmHg and DBP exceeded 82 mmHg. Each IQR increase in all five PM2.5 chemical constituents was associated with elevated SBP (β [95% CI]: 0.90 [0.75, 1.05]), DBP (β: 0.44 [0.34, 0.53]), and MAP (β: 0.57 [0.45, 0.69]), NH4+ (for SBP: weight = 99.43%; for DBP: 12.78%; for MAP: 60.73%) and BC (for DBP: 87.06%; for MAP: 39.07%) predominantly influencing these effects. The joint effect of PM2.5 chemical constituents on risks for elevated SBP and DBP exhibited an upward trend from the 70th quantile (SBP exceeded 133 mmHg, DBP exceeded 82 mmHg).
Conclusion: Long-term exposure to PM2.5 and its chemical constituents was associated with increased risk for elevated BP, with NH4+ and BC being the main contributors, and such associations were significantly stronger at 70th to 90th quantiles (SBP exceeded 133 mmHg, DBP exceeded 82 mmHg).
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 Wolters Kluwer Health, Inc. This is an author produced version of an article published in Journal of Hypertension. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | blood pressure, chemical constituent, hypertension, PM2.5, quantile regression |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Geography (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 03 Mar 2025 10:49 |
Last Modified: | 03 Mar 2025 10:49 |
Status: | Published |
Publisher: | Lippincott, Williams & Wilkins |
Identification Number: | 10.1097/hjh.0000000000003795 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:223912 |
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