Malkinson, G. and Henriques, C.M. orcid.org/0000-0003-1882-756X (2025) Cerebrovascular ageing: how zebrafish can contribute to solving the puzzle. Frontiers in Physiology, 16. 1548242. ISSN 1664-042X
Abstract
The mean life expectancy continues to increase world-wide. However, this extended lifespan trend is not accompanied by health span, or years of healthy life. Understanding the fundamental mechanisms responsible for the switch from health to morbidity with ageing are key to identifying potential therapeutic targets to decrease age-associated morbidity and increase years spent in good health. The leading cause of morbidity in Europe are diseases of the circulatory system and diseases of the nervous system and cognitive disorders are among the top-ten. Cerebrovascular ageing is therefore of particular importance as it links circulatory disease to brain functions, cognition, and behavior. Despite major progress in brain research and related technologies, little is known on how the cerebrovascular network changes its properties as ageing proceeds. Importantly, we do not understand why this is different in different individuals in what concerns rate of dysfunction and its downstream impact on brain function. Here we explore how the zebrafish has evolved as an attractive complementary ageing model and how it could provide key insights to understanding the mechanisms underlying cerebrovascular ageing and downstream consequences.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2025 Malkinson and Henriques. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
Keywords: | zebrafish; brain; telomere; telomerase; cerebrovascular; ageing |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Funding Information: | Funder Grant number WELLCOME TRUST (THE) 206224/Z/17/Z DUNHILL MEDICAL TRUST AISRPG2305\32 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 27 Feb 2025 14:45 |
Last Modified: | 27 Feb 2025 14:45 |
Status: | Published |
Publisher: | Frontiers Media SA |
Refereed: | Yes |
Identification Number: | 10.3389/fphys.2025.1548242 |
Sustainable Development Goals: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:223851 |