Trama, A., Lasalvia, P., Stark, D. orcid.org/0000-0002-6172-733X et al. (17 more authors) (2025) Incidence and survival of European adolescents and young adults diagnosed with sarcomas: EUROCARE-6 results. European Journal of Cancer, 217. 115212. ISSN 0959-8049
Abstract
Background Epidemiological data for sarcoma in adolescents and young adults (AYAs) and across age groups are limited. We aim to: 1) update sarcoma incidence, survival, and changes over time in European AYAs; 2) provide an updated comparison of sarcoma survival in AYAs versus children and mature adults.
Methods We calculated crude incidence rates (IR) per 100,000 European population per year from 2006 to 2013. Using the period approach, we calculated 5-year relative survival (RS) for the follow-up period 2010–2014. We estimated changes in incidence and survival for bone sarcoma (BS) and soft tissue sarcoma (STS) subtypes in AYAs in the years 2000–2013.
Findings In European AYAs, the IR was 0.81/100,000 for BS and 1.45/100,000 for STS. Five-year RS was 69 % and 65 % for BS and STS, respectively. Compared to children, AYAs had poorer survival for Ewing sarcoma of bone, synovial sarcoma, Ewing sarcoma of soft tissue and rhabdomyosarcoma. Compared to mature adults, AYAs had higher 5-year RS for all BS and for most of the STS subtypes. In AYAs, incidence increased for a few bone and soft tissue subtypes. Survival increased mainly for BS.
Interpretation The reason for the better survival observed in AYAs compared to mature adults is probably multifactorial. The limited improvement of STS survival in AYAs may reflect the relative absence of new drugs for STS during the study period. The increase in RS for BS might relate to general improvements in radiological and surgical approaches and radiotherapy techniques.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). |
Keywords: | Bone and soft tissue sarcoma; Incidence; Survival; Adolescents and young adults; Population-based cancer registries |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) |
Funding Information: | Funder Grant number EU - European Union 10039273 EU - European Union 261747 EU - European Union 261747 Teenage Cancer Trust NO EXT REF GIVEN NIHR National Inst Health Research NIHR300693 Teenage Cancer Trust Not Known Teenage Cancer Trust No Ref |
Depositing User: | Symplectic Publications |
Date Deposited: | 26 Feb 2025 16:45 |
Last Modified: | 26 Feb 2025 16:45 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.ejca.2024.115212 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:223769 |