Armutcu, F. orcid.org/0000-0002-3218-9480 and McCloskey, E. orcid.org/0000-0003-0177-8140 (2025) Fracture risk assessment in metabolic syndrome in terms of secondary osteoporosis potential. A narrative review. Calcified Tissue International, 116 (1). 41. ISSN 0171-967X
Abstract
Osteoporosis is a major global public health problem with the associated bone fractures contributing significantly to both morbidity and mortality. In many countries, osteoporotic fractures will affect one in three women and one in five men over the age of 50. Similarly, diabetes, obesity, and metabolic syndrome (MetS) are among the leading public health problems due to their worldwide prevalence and burden on health budgets. Although seemingly disparate, metabolic disorders are known to affect bone health, and the interaction between fat and bone tissue is increasingly well understood. For example, it is now well established that diabetes mellitus (both type 1 and 2) is associated with fracture risk. In this narrative review, we focus on the potential link between MetS and bone health as expressed by bone mineral density and fracture risk. This narrative review demonstrates the association of MetS and its components with increased fracture risk, and also highlights the need for fracture risk assessment in patients with obesity and MetS.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Metabolic syndrome; Obesity; Hyperglycemia; Insulin resistance; Secondary osteoporosis; Fracture risk assessment |
Keywords: | Metabolic syndrome; Obesity; Hyperglycemia; Insulin resistance; Secondary osteoporosis; Fracture risk assessment |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 24 Feb 2025 15:01 |
Last Modified: | 24 Feb 2025 15:01 |
Status: | Published |
Publisher: | Springer Science and Business Media LLC |
Refereed: | Yes |
Identification Number: | 10.1007/s00223-025-01341-5 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:223711 |